Condition 1: Schizoaffective Disorder. Condition 2: Schizophrenia. Schizoaffective disorder Schizophrenia
Conditions
Interventions
Intervention 1: Computer assisted cognitive remediation that consists of 10 training sessions using tasks in Cogpack software for improvement of memory, attention and executive functions. Sessions are
Rehabilitation
Treatment - Other
Computer assisted cognitive remediation that consists of 10 training sessions using tasks in Cogpack software for improvement of memory, attention and executive functions. Sessions are delivered in 2-
Treatment-as-usual that usually consists of antipsychotic medications in standard maintenance dosage prescribed by a physician and accompanied by patient education.
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Patients with DSM-IV schizophrenia or schizoaffective disorder, aged 18 to 55 years and with education not less than 3rd grade in guidance school. Patients will be clinically stable and not acutely psychotic (Clinical Global Impression scale score less than 4, and Positive and Negative Syndrome Scale score less than 50). The dosage and the type of antipsychotic medications patients will receive at least during the three weeks prior to the study will be unchanged. At least 12 hours before the intervention, patients will receive their last dose of a benzodiazepine (if any) but no antihistamine medication will be administered. Exclusion criteria: Receiving electroconvulsive therapy (ECT) within six weeks prior to the study, mental retardation, uncorrected visual impairment, concurrent consumption of substances with the exception of nicotine and caffeine, a history of head trauma followed by loss of consciousness, suffering from a major neurological disorder (including epilepsy, Parkinson’s disease, dementia, multiple sclerosis, or any motor disability), severe worsening of illness during study requiring a change in medical treatments.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Executive function. Timepoint: Before and after the intervention. Method of measurement: CANTAB Battery.;Attention. Timepoint: Before and after the intervention. Method of measurement: CANTAB Battery.;Memory. Timepoint: Before and after the intervention. Method of measurement: CANTAB Battery. | — |
Secondary
| Measure | Time frame |
|---|---|
| Global Function. Timepoint: Before and after the intervention. Method of measurement: Global Assessment of Functioning.;Quality of life. Timepoint: Before and after the intervention. Method of measurement: Quality of life questionnaire.;Severity of illness. Timepoint: Before and after the intervention. Method of measurement: Positive and Negative Syndrome Scale, and Clinical global impression. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAzadeh Sedighnia
Roozbeh Hospital
Outcome results
None listed