COVID19.
Conditions
Sponsors
Ghoum University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Laboratory confirmation of Covid19 infection with reverse transcription polymerase chain reaction (RT-PCR) from any diagnostic sampling source A new organ dysfunction related to Covid19 Being an adult
Exclusion criteria
Exclusion criteria: Intention to commit suicide (interfering with interferon (IFN) -b1b). Sensitivity or sensitivity reaction to Lupinavir / Ritonavir or IFN-ß1b recombinant, including toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema or angioedema syndrome. ALT above 5 times normal Use of drugs that are contraindicated with lopinavir / ritonavir and should not be substituted or discontinued during the study period, such as CYP3A inhibitors. pregnancy.Eligible female participants are tested at gestational age before enrolling in the study for pregnancy. HIV Vulnerable groups
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Death within 30 days of hospitalization. Timepoint: every day. Method of measurement: View. | — |
Secondary
| Measure | Time frame |
|---|---|
| Days without organ support (for example, supplemental O2, mechanical ventilation, dialysis and vasopressors). Timepoint: Time interval: 28 days. Method of measurement: View.;Results of RT-PCR in lower respiratory samples. Timepoint: Time interval: At the time of entering the study and one week after treatment and repetition every week until the negative sample of the period. Method of measurement: test.;Body Failure Assessment Scores (SOFA). Timepoint: Time frame: days 1, 3, 5, 7, 14 and 28). Method of measurement: check list. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contactjamsheed vafaeemanesh
Ghoum University of Medical Sciences
Outcome results
None listed