Effect of adjunctive locally delivered doxycycline microspheres on clinical parameters and the gingival crevicular fluid matrix metalloproteinase-8 levels in chronic periodontitis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201601173690N6

Enrollment

Registered

2016-03-13

Start date

2016-02-18

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic periodontitis. Chronic periodontitis

Interventions

Intervention 1: Test group: Initial sampling was carried out before every intervention to determine mmp8 level of gingival crevicular fluid and evaluate clinical parameters including probe depth, atta

Treatment - Drugs

Test group: Initial sampling was carried out before every intervention to determine mmp8 level of gingival crevicular fluid and evaluate clinical parameters including probe depth, attachment level and

Control groupInitial sampling was carried out before every intervention to determine mmp8 amount of Gingival Crevicular fluid and evaluate clinical parameters including probe depth, Attachment level

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients with moderate to severe chronic periodontitis with at least 4 teeth and 4-6mm probe depth were included in the study whose two teeth were at one quadrantand the other two teeth at opposite quadrant of the same patient. The patients shouldn’t have sensitivity to antibiotics of tetracycline group and they also, should not have periodontal treatment till 6 months before. Moreover they shouldn’t take antibiotics 3 months before treatment. Finally they shouldn’t have systemic problem which affects periodontal tissues. If the patient had one of following cases, he would be excluded from the study: Having SRP and every periodontal treatment till 6 months before the study, presence of every systemic disorder affecting periodontal position, having allergy history to doxycycline or antibiotics of tetracycline group and taking antibiotics 3 months before the study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Gingival crevicular fluid matrix metalloproteinase-8 levels. Timepoint: Baseline , 1 and 3 months after treatment. Method of measurement: Ng/ml ,ELISA using Quantikine human total MMP-8 immunoassay kits.	—

Secondary

Measure	Time frame
Evaluation of prob depth , attachment level and bleeding of probing. Timepoint: Baseline, 1and 3 months after treatment. Method of measurement: By prob , pocket depth and attachment level :mm.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr zahra marami gezelje

Faculty of dentestery

Marami-zahra@yahoo.com+98 41 3335 5968

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026