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Investigating the effect of postbiotic and thyme on saliva Streptococcus bacterial count

Production and investigation of antibacterial effects of toothpaste containing postbiotic yeast Saccharomyces boulardi and Zataria multiflora extract and its effect on Streptococcus mutans levels in saliva: a randomized controlled trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20160117026069N11
Enrollment
60
Registered
2025-08-12
Start date
2025-08-02
Completion date
Unknown
Last updated
2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental caries. Dental caries

Interventions

Intervention 1: Intervention group: Using toothpaste containing postbiotics and thyme extract for ten days, twice a day after breakfast and dinner. Intervention 2: Control group: Using toothpaste cont

Sponsors

Karaj University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Volunteers without active dental caries, as confirmed by a dentist, will be selected.

Exclusion criteria

Exclusion criteria: Individuals who consume antibiotics or certain medications will be excluded from the study. Individuals with allergies or sensitivities in the oral cavity will be excluded from the study. Individuals with unusual dietary habits, such as sugar addiction or habitual consumption of sugary beverages (e.g., soda, energy drinks), will be excluded from the study. Participants who are on any dietary regimen will be excluded from the study.

Design outcomes

Primary

MeasureTime frame
Streptococcus mutans count in saliva. Timepoint: Before study and 10 days after treatment. Method of measurement: Bacterial count in saliva culture.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNezam Armand

Karaj University of Medical Sciences

armandnezam@yahoo.com+98 26 3464 3705

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026