Ischemic reperfusion injury in chronic artery bypass graft surgery. Chronic ischaemic heart disease
Conditions
Interventions
Intervention 1: Infusion of 50cc normal saline as placebo in control group, during aortic clamping(45-60 minutes). Intervention 2: Infusion of 60000 IU erythropoietin in intervention group,during aort
Treatment - Drugs
Infusion of 50cc normal saline as placebo in control group, during aortic clamping(45-60 minutes)
Infusion of 60000 IU erythropoietin in intervention group,during aortic clamping (45-60 minutes)
Sponsors
Pooyesh Darou company and Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: The inclusion criterion are revascularization requirement according to angiographic evidence,cronary artery bypass graft (CABG) surgery in elective situation, for the first time and with cardiopulmonary bypass(CPB). The exclusion criteria are comprised of history of myocardial infarction in the past 3 months, previous myocardial trauma or major surgery in the past 3 months, Cr>2, receiving streptokinase or previous reperfusion treatments, EPO intake in the recent 6 months, known thrombo-embolic disorder, malignant disease,uncontrolled hypertension and polycythemia
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Interleukin 6. Timepoint: before operation (base),just after operation,24 hours after operation,48 hours after operation. Method of measurement: elisa.;YKL-40. Timepoint: before operation (base),just after operation,24 hours after operation,48 hours after operation. Method of measurement: elisa.;TNF-a. Timepoint: before operation (base),just after operation,24 hours after operation,48 hours after operation. Method of measurement: elisa.;Added at 2016-09-22: B type natriuretic peptide(BNP. Timepoint: before operation (base),just after operation,24 hours after operation,48 hours after operation. Method of measurement: Added at 2016-09-22: ELISA. | — |
Secondary
| Measure | Time frame |
|---|---|
| CPK-MB. Timepoint: befor operation(base),6 hour after operation,12 hour after operation. Method of measurement: elisa.;Bleeding. Timepoint: during operation,6 hour after operation,12 hour after operation,24 hour after operation. Method of measurement: volume of bleeeding.;Troponin. Timepoint: befor operation(base),6 hour after operation,12 hour after operation. Method of measurement: elisa. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contactdr foroughi
heart surgery department ofShahid Modarres hospital
Outcome results
None listed