the effect of Isoflurane anesthesia gas on blood circulation and bleeding in patients undergoing surgery

Effect of isoflurane on bleeding and hemodynamic changes in patiants undergoing endoscopic sinus surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016011526025N1

Enrollment

Registered

2016-02-04

Start date

2015-10-18

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intraoperative bleeding. Unintentional cut, puncture, perforation or haemorrhage during surgical and medical care

Interventions

Intervention 1: Intervention group 2: Prescription 1.2 MAC of isoflurane as a maintenance of anesthesia during surgery. Intervention 2: Control group: Prescription 0.8 MAC of isoflurane as a maintenan

Prevention

Intervention group 2: Prescription 1.2 MAC of isoflurane as a maintenance of anesthesia during surgery.

Control group: Prescription 0.8 MAC of isoflurane as a maintenance of anesthesia during surgery.

Intervention group1: Prescription 1 MAC of isoflurane as a maintenance of anesthesia during surgery.

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Patients candidate for sinus surgery; ASA (American society of anesthesiology) physical class one and two; Patient with ages: 18-50 years old. Exclusion Criteria: History of kidney problems; Heart disease; Liver disease; Drug allergy to isoflurane; Lack of patient satisfaction.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Body mass index (BMI). Timepoint: Before the start of surgery. Method of measurement: Using the formula: weight (kg) / the square of the height (m).;The amount of hemoglobin. Timepoint: Immediately before surgery and immediately after surgery and 6 hours after surgery. Method of measurement: Venous sampling and sent to the laboratory.;The amount of hematocrit. Timepoint: Immediately before surgery and immediately after surgery and 6 hours after surgery. Method of measurement: Venous sampling and sent to the laboratory.;Bleeding (By calculating the difference between pre- and postoperative hemoglobin(Hb)). Timepoint: After surgery. Method of measurement: Using the formula: CBL= BV×(Hb loss/Hb per), Hb loss = Hb pre – Hb post + t (The number of injected packed red blood cell units).;Bleeding (By calculating the difference between pre- and postoperative hematocrit(Hct)). Timepoint: After surgery. Method of measurement: Using the formula: CBL = RBCL / [(HCTper+HCTpost)/2], RBCL = BV × (Hct pre – Hct post) + 320 t.	—

Measure

Time frame

Body mass index (BMI). Timepoint: Before the start of surgery. Method of measurement: Using the formula: weight (kg) / the square of the height (m).;The amount of hemoglobin. Timepoint: Immediately before surgery and immediately after surgery and 6 hours after surgery. Method of measurement: Venous sampling and sent to the laboratory.;The amount of hematocrit. Timepoint: Immediately before surgery and immediately after surgery and 6 hours after surgery. Method of measurement: Venous sampling and sent to the laboratory.;Bleeding (By calculating the difference between pre- and postoperative hemoglobin(Hb)). Timepoint: After surgery. Method of measurement: Using the formula: CBL= BV×(Hb loss/Hb per), Hb loss = Hb pre – Hb post + t (The number of injected packed red blood cell units).;Bleeding (By calculating the difference between pre- and postoperative hematocrit(Hct)). Timepoint: After surgery. Method of measurement: Using the formula: CBL = RBCL / [(HCTper+HCTpost)/2], RBCL = BV × (Hct pre – Hct post) + 320 t.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactArtadokht Khoshooei

Ahvaz Jundishapur University of Medical Sciences

Ar_khoshooei@yahoo.com+98 61 3222 2922

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026