Comparison between clonidine and Dexmedetomidine as premedication on hemodynamic changes and intraoperative bleeding

Comparison between clonidine and Dexmedetomidine as premedication on hemodynamic changes and intraoperative bleeding in spine surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016011225982N1

Enrollment

120

Registered

2016-01-25

Start date

2015-05-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Bleeding. Condition 2: Hemodynamic Changes. Complications of procedures, not elsewhere classified Tachycardia (unspecified), Bradycardia (unspecified), Palpitations

Interventions

Intervention 1: The first group intervention: clonidine 0.2 mg tablets 45 minutes before induction of anesthesia and saline infusion as a placebo to 100 ml 15 minutes before induction of anesthesia. I

Treatment - Other

Placebo

The first group intervention: clonidine 0.2 mg tablets 45 minutes before induction of anesthesia and saline infusion as a placebo to 100 ml 15 minutes before induction of anesthesia

The second group intervention: placebo tablets and infusion Dexmedetomidine 0.5 micrograms per kg in 100 mL normal saline 15 minutes before induction of anesthesia to continue the infusion of 0.25 mg

Control group: placebo tablets with 100 mL of normal saline infusion took 15 minutes before induction of anesthesia

Eligibility

Sex/Gender

All

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria were as follows: age range of 20 to 50 years, ASA class 1 or 2 and spine surgery candidates. Exclusion criteria included patients with hypertension, diabetes, clotting problems, ischemic heart disease, drug or alcohol abuse, pregnancy, taking beta blockers or calcium channels blockers drugs and operating time of over 120 minutes.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Intraoperative bleeding. Timepoint: Ending surgery. Method of measurement: Including suction bottle and blood gauzes.	—

Secondary

Measure	Time frame
Heart Rate. Timepoint: One minute after intubation, 10, 20, 30 minutes after induction of anesthesia and after extubation. Method of measurement: ECG Monitoring.;Blood Pressure. Timepoint: One minute after intubation, 10, 20, 30 minutes after induction of anesthesia and after extubation. Method of measurement: Invasive blood pressure monitoring.;Mean Arterial Pressure. Timepoint: One minute after intubation, 10, 20, 30 minutes after induction of anesthesia and after extubation. Method of measurement: Invasive blood pressure monitoring.	—

Measure

Time frame

Heart Rate. Timepoint: One minute after intubation, 10, 20, 30 minutes after induction of anesthesia and after extubation. Method of measurement: ECG Monitoring.;Blood Pressure. Timepoint: One minute after intubation, 10, 20, 30 minutes after induction of anesthesia and after extubation. Method of measurement: Invasive blood pressure monitoring.;Mean Arterial Pressure. Timepoint: One minute after intubation, 10, 20, 30 minutes after induction of anesthesia and after extubation. Method of measurement: Invasive blood pressure monitoring.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahshid Vaziri

Ahvaz Jundishapur University of Medical Sciences

vaziri.m@ajums.ac.ir+98 61 3221 6504

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026