Comparison the effect of sodium bicarbonate and zinc chloride mouth washes on incidence and severity of oral mucositis

Comparison the effect of sodium bicarbonate and zinc chloride mouth washes on incidence and severity of oral mucositis in patients with cancer under chemotherapy

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160110025929N28

Enrollment

144

Registered

2019-09-28

Start date

2019-09-23

Completion date

Unknown

Last updated

2019-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral mucositis. Oral mucositis (ulcerative)

Interventions

Intervention 1: Intervention group(1): patients receive 5% sodium bicarbonate solution every 8 hours, 2 times for 21 days. Intervention 2: Intervention group(2): patients will receive 0.5% zinc c

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with cancer aged 18 to 65 years Cancer stage 1 or 2 Absence of oral ulcers No sensitivity to zinc chloride and sodium bicarbonate

Exclusion criteria

Exclusion criteria: Absence on at least one day from the days designated for follow-up Dissatisfaction with continuing to participate in the study

Design outcomes

Primary

Measure	Time frame
Incidence and severity of oral mucositis. Timepoint: Before and up to twenty days after the intervention. Method of measurement: World Health Organization Mucositis Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Mohamadi

Hamedan University of Medical Sciences

f.Mohammadi@umsha.ac.ir+98 81 3838 0535

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026