Keloid. Hypertrophic scar
Conditions
Interventions
Intervention 1: Intervention group: Intralesional injection of maximum 1 milliliter of verapamil hydrochloride (2.5 milligram per milliliter) every 3 weeks till the scar flattened or for a maximum per
Treatment - Drugs
Intervention group: Intralesional injection of maximum 1 milliliter of verapamil hydrochloride (2.5 milligram per milliliter) every 3 weeks till the scar flattened or for a maximum period of 6 months.
Control group: Intralesional injection of maximum 1 milliliter of triamcinolone acetonide (40 milligram per milliliter) every 3 weeks till the scar flattened or for a maximum period of 6 months. The i
Sponsors
Vice chancellor fpr research of Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: age over 18 years; two or more hypertrophic scars or keloids; total area less than 10 square centimeters; no previous treatment; scars under 5 years duration Exclusion criteria: Facial keloids; infection or ulcer, in or near the scar; pregnancy and lactation; patients with systemic illness like diabetes mellitus, mental disorder, cancer and cardiac disease; dark pigmented skin
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scar pigmentation. Timepoint: Before intervention, every 3 weeks for a period of 6 months, 3 months after the end of the intervention. Method of measurement: Observation and scoring based on Vancouver Scar Scale.;Height of the scar. Timepoint: Before intervention, every 3 weeks for a period of 6 months, 3 months after the end of the intervention. Method of measurement: Using ruler and scoring based on Vancouver Scar Scale.;Vascularity. Timepoint: Before intervention, every 3 weeks for a period of 6 months, 3 months after the end of the intervention. Method of measurement: visual inspection and the rate of refill after blanching and scoring based on Vancouver Scar Scale.;Scar pliability. Timepoint: Before intervention, every 3 weeks for a period of 6 months, 3 months after the end of the intervention. Method of measurement: Palpation and scoring based on Vancouver Scar Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient's satisfaction. Timepoint: At the end of the study. Method of measurement: Asking the patients about any alternation in side effects of the keloids e.g. pain and pruritus. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactPardis Sasani
Tehran University of Medical Sciences
Outcome results
None listed