Comparison of different methods of tranexamic acid administration on post operative blood loss

Evaluation of the effects of Three Methods of Tranexamic Acid Administration on post operative blood loss following total knee arthroplasty compared with the control group

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160105025871N2

Enrollment

200

Registered

2019-10-19

Start date

2019-09-23

Completion date

Unknown

Last updated

2019-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Amount of bleeding following total knee arthroplasty. Presence of unspecified artificial knee joint

Interventions

Intervention 1: Intervention group: 10 mg/kg of intravenous tranexamic acid in 100 cc of normal saline will be administrated following wound closure. The drain will be clamped for an hour. Interventio

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who scheduled to undergo a unilateral total knee arthroplasty

Exclusion criteria

Exclusion criteria: Cardiovascular diseases Cerebrovascular diseases Bleeding disorders Known allergy to tranexamic acid Receiving the anti-coagulant drugs History of thromboembolic disease

Design outcomes

Primary

Measure	Time frame
The amount of hemoglobin. Timepoint: Preoperatively, 24 hours postoperatively and in the morning discharge day. Method of measurement: Complete Blood Count (CBC) test.;Post-operative drained blood volume. Timepoint: 48 hours after the operation. Method of measurement: Hemovac drain.	—

Secondary

Measure	Time frame
Surgical site infection. Timepoint: 48 hours postoperatively. Method of measurement: clinical examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBehnam Behmardi Kalantari

Kerman University of Medical Sciences

pardis_sasani@yahoo.com+98 34 3212 2405

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026