Effect of supplementation in treatment of women with cervical intraepithelial neoplasia 2 and 3

Clinical trial of the effect of vitamin D supplementation compared with the placebo on recurrence and metabolic profiles in women with cervical intraepithelial neoplasia 2 and 3

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201601045623N65

Enrollment

Registered

2016-01-04

Start date

2015-12-22

Completion date

Unknown

Last updated

2019-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cervical intraepithelial neoplasia 2 and 3. Cervix uteri, unspecified

Interventions

Intervention 1: Intervention group: Vitamin D supplement, 50000 IU, every 2 weeks, for 6 months orally. Intervention 2: Control group: Placebo, every 2 weeks, for 6 months orally.

Eligibility

Sex/Gender

Female

Age

25 Years to 65 Years

Inclusion criteria

Inclusion criteria: Women with cervical intraepithelial neoplasia 2 and 3 Aged 25 to 65 years old

Exclusion criteria

Exclusion criteria: Women who had a history of cervical cancer or other cancers of the lower genital tract History of hysterectomy or destructive therapy of the cervix Pregnant women

Design outcomes

Primary

Measure	Time frame
Recurrence. Timepoint: Six months after intervention. Method of measurement: Colposcopy.	—

Secondary

Measure	Time frame
Insulin. Timepoint: At the beginning of the study and after 6 months of intervention. Method of measurement: Elisa kit.;Nitric oxide. Timepoint: At the beginning of the study and after 6 months of intervention. Method of measurement: Spectrophotometry.;Hs-CRP. Timepoint: At the beginning of the study and after 6 months of intervention. Method of measurement: Elisa kit.;Triglycerides. Timepoint: At the beginning of the study and after 6 months of intervention. Method of measurement: Enzymatic kit.;Cholesterol. Timepoint: At the beginning of the study and after 6 months of intervention. Method of measurement: Enzymatic kit.;Total antioxidant. Timepoint: At the beginning of the study and after 6 months of intervention. Method of measurement: Spectrophotometry.;Malondialdehyde. Timepoint: At the beginning of the study and after 6 months of intervention. Method of measurement: Spectrophotometry.;Fasting blood sugar. Timepoint: At the beginning of the study and after 6 months of intervention. Method of measurement: Baseline and End-of-trial.;Serum vitamin D. Timepoint: At the beginning of the study and after 6 months of intervention. Method of measurement: Elisa kit.;HDL. Timepoint: At the beginning of the study and after 6 months of intervention. Method of measurement: Enzymatic kit.;Insulin resistance. Timepoint: At the beginning of the study and after 6 months of intervention. Method of measurement: Calculation using HOMA formula.	—

Measure

Time frame

Insulin. Timepoint: At the beginning of the study and after 6 months of intervention. Method of measurement: Elisa kit.;Nitric oxide. Timepoint: At the beginning of the study and after 6 months of intervention. Method of measurement: Spectrophotometry.;Hs-CRP. Timepoint: At the beginning of the study and after 6 months of intervention. Method of measurement: Elisa kit.;Triglycerides. Timepoint: At the beginning of the study and after 6 months of intervention. Method of measurement: Enzymatic kit.;Cholesterol. Timepoint: At the beginning of the study and after 6 months of intervention. Method of measurement: Enzymatic kit.;Total antioxidant. Timepoint: At the beginning of the study and after 6 months of intervention. Method of measurement: Spectrophotometry.;Malondialdehyde. Timepoint: At the beginning of the study and after 6 months of intervention. Method of measurement: Spectrophotometry.;Fasting blood sugar. Timepoint: At the beginning of the study and after 6 months of intervention. Method of measurement: Baseline and End-of-trial.;Serum vitamin D. Timepoint: At the beginning of the study and after 6 months of intervention. Method of measurement: Elisa kit.;HDL. Timepoint: At the beginning of the study and after 6 months of intervention. Method of measurement: Enzymatic kit.;Insulin resistance. Timepoint: At the beginning of the study and after 6 months of intervention. Method of measurement: Calculation using HOMA formula.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZatollah Asemi

Kashan University of Medical Sciences

asemi_r@yahoo.com+98 31 5546 3378

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026