Diabetic nephropathy. Glomerular disorders in diabetes mellitus
Conditions
Interventions
Intervention 1: Soy milk containing lactobacillus plantarum A7, 200 cc orally, once a day for 2 months. Intervention 2: Soy milk without lactobacillus plantarum A7 , 200 cc orally, once a day for 2 mo
Treatment - Other
Soy milk containing lactobacillus plantarum A7, 200 cc orally, once a day for 2 months
Soy milk without lactobacillus plantarum A7 , 200 cc orally, once a day for 2 months
Sponsors
Isfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: Having T2DM ;having micro or macro albuminuria ;GFR higher than 60 ml/min ;not having hepatic gastrointestinal and thyroid diseases ;not having rheumatoid arthritis ;not having any kind of allergy or acute infection ;not consuming vitamin mineral or omega-3 supplements 3 weeks before beginning of the trial and during the trial ;not consuming antibiotics 1 month before the trial and during the trial ;absence of pregnancy or lactating ;not smoking ;not having any specific diet. Exclusion criteria: Not adhering to the administrated diet ;occurrence of other kidney diseases ;cardiac ischemia ;gastrointestinal ;hepatic or thyroid diseases ;acute infection ;needing to be dialysed ;undergoing kidney transplantation ;any kind of surgery or occurrence of pregnancy ;starting to consume drugs that may affect protein excretion such as NSAIDs or ACE-I.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum creatinine. Timepoint: Before the intervention and 2 months after beginning of the intervention. Method of measurement: mg/dl , biochemical analysis.;Proteinuria. Timepoint: Before the intervention and 2 months after beginning of the intervention. Method of measurement: mg/day, Biochemical analysis.;IL-18. Timepoint: Before the intervention and 2 months after beginning of the intervention. Method of measurement: ?g/ml , ELISA.;Serum sialic acid. Timepoint: Before the intervention and 2 months after beginning of the intervention. Method of measurement: mmol/l , ELISA.;TNF-a. Timepoint: Before the intervention and 2 months after beginning of the intervention. Method of measurement: ?g/ml , ELISA.;HsCRP. Timepoint: Before the intervention and 2 months after beginning of the intervention. Method of measurement: mg/dl , ELISA.;GFR. Timepoint: Before the intervention and 2 months after beginning of the intervention. Method of measurement: ml/min , calculation.;Serum cholestrol. Timepoint: Before the intervention and 2 months after beginning of the intervention. Method of measurement: mg/dl , biochemical analysis.;Serum triglyceride. Timepoint: Before the intervention and 2 months after beginning of the intervention. Method of measurement: mg/dl , biochemical analysis.;Serum LDL-C. Timepoint: Before the intervention and 2 months after beginning of the intervention. Method of measurement: mg/dl , biochemical analysis.;Serum HDL-C. Timepoint: Before the intervention and 2 months after beginning of the intervention. Method of measurement: mg/dl , biochemical analysis.;Physical activity. Timepoint: Before the intervention and 2 months after beginning of the intervention. Method of measurement: Met-h/wk , Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum sodium. Timepoint: Before the intervention and 2 months after beginning of the intervention. Method of measurement: mg/dl ,flame photometry.;Serum potassium. Timepoint: Before the intervention and 2 months after beginning of the intervention. Method of measurement: mg/dl ,flame photometry.;Fasting blood sugar. Timepoint: Before the intervention and 2 months after beginning of the intervention. Method of measurement: mg/dl , Biochemical analysis.;Serum genistein. Timepoint: Before the intervention and 2 months after beginning of the intervention. Method of measurement: nmol/l , TR-FIA. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBehnood Abbasi
Isfahan University of Medical Sciences
Outcome results
None listed