Effect of Curcumin on Osteoprosis in patient with Spinal Cord Injury

Effect of Curcumin on bone density loss and biochemical marker of bone turn over in patient with Spinal Cord Injury

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016010225805N1

Enrollment

100

Registered

2016-04-21

Start date

2015-10-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

spinal cord injury. Injury of spinal cord, level unspecified

Interventions

Intervention 1: Control group: Calcium Plus(Caspian Tamin co, Iran) 1000 mg daily for 6 months. Intervention 2: Intervention group: Curcumin (Mina Laboratory co,Iran) 110 mg/kg daily for 6 months+ Cal

Treatment - Drugs

Control group: Calcium Plus(Caspian Tamin co, Iran) 1000 mg daily for 6 months

Intervention group: Curcumin (Mina Laboratory co,Iran) 110 mg/kg daily for 6 months+ Calcium Plus 1000 mg daily for 6 months.

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: age equal to 18 years; trauma; recent SCI (less than 6 months); paraplegia or quadriplegia move engagement protocol spinal cord injury America Association (ASIA). Exclusion criteria: any secondary cause of osteoporosis such as metabolic or endocrine disease; osteogenesis imperfecta; tumors; chronic cardiovascular diseases; liver; anti-osteoporosis medications during the selection of patients; Alcoholism; pregnancy; chronic use of steroids; smoking; older than 70

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Bone Density of Total Hip. Timepoint: Before intervention and 6 month after intervetion. Method of measurement: Dansitometry Lab.;Bone Density of lumbar vertebral (L1-L4). Timepoint: Before intervention and 6 month after intervetion. Method of measurement: Laboratory assay.;Bone Density of Femoral Neck. Timepoint: Before intervention and 6 month after intervetion. Method of measurement: Laboratory assay.;Bone Specific alkaline phsphatase. Timepoint: Before intervention , 3 month after intervention and 6 month after intervetion. Method of measurement: ElISA.;Propeptide amino-terminal of type I procollagen. Timepoint: Before intervention and 6 month after intervetion. Method of measurement: ElISA.;Osteoclacin. Timepoint: Before intervention and 6 month after intervetion. Method of measurement: ElISA.	—

Measure

Time frame

Bone Density of Total Hip. Timepoint: Before intervention and 6 month after intervetion. Method of measurement: Dansitometry Lab.;Bone Density of lumbar vertebral (L1-L4). Timepoint: Before intervention and 6 month after intervetion. Method of measurement: Laboratory assay.;Bone Density of Femoral Neck. Timepoint: Before intervention and 6 month after intervetion. Method of measurement: Laboratory assay.;Bone Specific alkaline phsphatase. Timepoint: Before intervention , 3 month after intervention and 6 month after intervetion. Method of measurement: ElISA.;Propeptide amino-terminal of type I procollagen. Timepoint: Before intervention and 6 month after intervetion. Method of measurement: ElISA.;Osteoclacin. Timepoint: Before intervention and 6 month after intervetion. Method of measurement: ElISA.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Mohammad Reza Hafezi Ahmadi

Ilam University of Medical Sciences

reza.ahmadi65@yahoo.com; hafezi-m@medilam.ac.ir+98 84 3224 3320

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026