weaning nasal continuous positive airway pressure (NCPAP) in premature neonates with respiratory distress syndrome

Investigate various strategies for weaning nasal continuous positive airway pressure (NCPAP) in premature neonates with respiratory distress syndrome

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160102025811N5

Enrollment

Registered

2021-04-05

Start date

2019-03-21

Completion date

Unknown

Last updated

2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory distress syndrome. Respiratory distress syndrome of newborn

Interventions

Intervention 1: Premature infants 26 to 32 weeks with respiratory distress syndrome, with a positive airway end pressure of 5 and an fraction of inspired oxygen of 30%, Infants underwent respiratory

Eligibility

Sex/Gender

All

Age

104 Days to 224 Days

Inclusion criteria

Inclusion criteria: Premature infants 26 to 32 weeks and six days with respiratory distress syndrome (premature onset of respiratory distress in the first 4 hours of life or radiographic findings in favor of respiratory distress syndrome) Positive airway pressure has been implicated in neonatal intensive care unit (NICU).

Exclusion criteria

Exclusion criteria: Infants with chromosomal defects Infants with severe congenital anomalies or severe congenital heart disease Infants with sphincter with Apgar less than 7 minutes Infants under mechanical ventilation Revived (advanced) babies Babies with parental dissatisfaction with entering the study

Design outcomes

Primary

Measure	Time frame
Respiratory distress syndrome score. Timepoint: Prior to intervention in all study groups and daily at specified times until discontinuation of respiratory support. Method of measurement: Score based on the number of breaths, need for oxygen, retraction, moaning, breathing sounds , immaturity.;Apnea. Timepoint: Before the intervention and at certain times daily after the intervention until the cessation of respiratory support. Method of measurement: Number of respiratory arrests per hour.;Duration of hospitalization. Timepoint: From the beginning to the end of the patient's hospitalization. Method of measurement: Number of days spent in the hospital.;Need to oxygen therapy. Timepoint: Before intervention and daily at specified times until discontinuation of respiratory support. Method of measurement: 10% increase in fraction of inspired oxygen(yes/no).;Retinopathy of Prematurity. Timepoint: At 28 days of birth. Method of measurement: Ophthalmological consultation.;Intraventricular haemorhage. Timepoint: At the end of intervention. Method of measurement: Brain sonography.;Respiratory Distress Syndrome. Timepoint: at the end of intervention. Method of measurement: Need oxygen after discharge.;Mortallity. Timepoint: At the end of intervention. Method of measurement: Neonate death.	—

Measure

Time frame

Respiratory distress syndrome score. Timepoint: Prior to intervention in all study groups and daily at specified times until discontinuation of respiratory support. Method of measurement: Score based on the number of breaths, need for oxygen, retraction, moaning, breathing sounds , immaturity.;Apnea. Timepoint: Before the intervention and at certain times daily after the intervention until the cessation of respiratory support. Method of measurement: Number of respiratory arrests per hour.;Duration of hospitalization. Timepoint: From the beginning to the end of the patient's hospitalization. Method of measurement: Number of days spent in the hospital.;Need to oxygen therapy. Timepoint: Before intervention and daily at specified times until discontinuation of respiratory support. Method of measurement: 10% increase in fraction of inspired oxygen(yes/no).;Retinopathy of Prematurity. Timepoint: At 28 days of birth. Method of measurement: Ophthalmological consultation.;Intraventricular haemorhage. Timepoint: At the end of intervention. Method of measurement: Brain sonography.;Respiratory Distress Syndrome. Timepoint: at the end of intervention. Method of measurement: Need oxygen after discharge.;Mortallity. Timepoint: At the end of intervention. Method of measurement: Neonate death.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMirhadi Mousavi

Tabriz University of Medical Sciences

drmussavihadi@yahoo.com+98 41 3327 2094

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026