Comparison the effects of analgesic drugs on vital signs in intra-tracheal intubation in preterm neonates

Comparison the effects of remifentanyl combined with atropine with fentanyl and remifentanyl alone on vital signs in non-emergent intra-tracheal intubation in preterm neonates

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160102025811N3

Enrollment

Registered

2020-02-04

Start date

2020-01-21

Completion date

Unknown

Last updated

2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neonates with respiratory distress. Respiratory distress of newborn

Interventions

Intervention 1: Intervention group: 1) Fentanyl 2 µg/kg and then intubation. Intervention 2: Intervention group:2) Remifentanyl 1µg/kg and then intubation. Intervention 3: Intervention group: 3) Atrop

Eligibility

Sex/Gender

All

Age

1 Days to 3 Days

Inclusion criteria

Inclusion criteria: Preterm neonates (27-34 week-old) in need of Surfactant administration Without any major anomalies Parents agree to participate in research Respiratory Score of neonates under 8 based on Critical care of the neonate

Exclusion criteria

Exclusion criteria: No need for intubation Neonates with family history of Myasthenia gravis Major anomalies

Design outcomes

Primary

Measure	Time frame
Systemic blood pressure. Timepoint: 1-3 days old. Method of measurement: Monitoring device.;Heart rate. Timepoint: 1-3 days old. Method of measurement: Monitoring device.;Hypoxia severity. Timepoint: 1-3 days old. Method of measurement: Pulsoxymeter.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMirHadi mousavi

Tabriz University of Medical Sciences

mirhadimousavi33@yahoo.com+98 41 3526 2255

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026