studying the brain tissue oxymetry. Intraventricular (nontraumatic) haemorrhage, grade 3, of fetus and newborn
Conditions
Interventions
Intervention 1: Control Group:
In this group, neonates are treated with nCPAP for two hours with two-hour intervals. Intervention 2: Intervention Group:
In this group, neonates are treated with NIPPV
Treatment - Other
Control Group:
In this group, neonates are treated with nCPAP for two hours with two-hour intervals
Intervention Group:
In this group, neonates are treated with NIPPV for two hours with two-hour intervals
Sponsors
Isfahan University of Medical Sciences-Vice chancellery of Research and Technology
Eligibility
Sex/Gender
All
Age
3 Days to 14 Days
Inclusion criteria
Inclusion criteria: Inclusion Criteria: preterm infants weighing less than 1500 gr who had been put under nCPAP respiratory support within 72 hours from birth due to RDS, and also received their first surfactant administration during the first two hours; RDS symptoms such as tachypnea, intercostal retraction, nasal flaring, grunting, and radiography suggestive of RDS; Survanta administration to achieve FiO2=30% and CDP=5 cm H2O in order to maintain SpO2 in the range of 89-95% in the right hand; IF at 72 hours from birth, newborns were under nCPAP respiratory support, and if in order to maintain SpO2 in the range of 89-95% in the right hand, CDP was in the range of 4 to 6 cm H2O, with FiO2 at 30% to 40%. EXCLUSION CRITERIA: Prenatal Asphyxia (5 min Apgar between 0 to 3, umbilical cord pH less than 7, and umbilical cord Bicarbonate less than 12mEq/L), and congenital disorders; newborns whose first dose of surfactant was administered later than 2 hours from birth; newborns who did not receive surfactant; newborns whose echocardigraphy revealed PDA symptoms; newborns who are under inotrope drugs administration; newborns whose cranial sonography suggested grade III to IV GM-IVH; newborns with air leak symptoms
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain tissue oxygenation. Timepoint: third day, seventh day, fourteenth day. Method of measurement: Near Infrared Spectroscopy. | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraventicular hemorrhage. Timepoint: daily. Method of measurement: transcranial sonography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Alireza Sadeghnia
Isfahan University of Medical Sciences
Outcome results
None listed