Comparing second-line treatment regimens for H. pylori

Comparison of two anti helicobacterpylori second-line regiments in patients with peptic ulcer disease after failure of first line triple drug regiment

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015123025770N1

Enrollment

120

Registered

2016-07-07

Start date

2014-03-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peptic Ulcer. Gastroduodenal Ulcer NOS

Interventions

Intervention 1: in OLA group : patients will be treated with : omeprazole 40 mg daily, levofloxacin 500 mg and amoxicillin 2 g for 2 weeks. Intervention 2: in OFAB group patients will be treated with:

Treatment - Drugs

in OLA group : patients will be treated with : omeprazole 40 mg daily, levofloxacin 500 mg and amoxicillin 2 g for 2 weeks

in OFAB group patients will be treated with: omeprazole 40 mg, 480 mg bismuth subcitrate, furazolidone 400 mg and amoxicillin 2 g for 2 weeks

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: All patients with peptic ulcer confirmed by endoscopy;Perfect for first-line treatment;Resistance and non-response to first-line therapy for Helicobacter pylori eradication Exclusion criteria: lack of regular use of antibiotics because of severe side effects.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
H.Pylori Eradication. Timepoint: After Intervention. Method of measurement: Percent.	—

Secondary

Measure	Time frame
Peptic Ulcer cure. Timepoint: after intervention. Method of measurement: Percent.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Laleh Abbasi

Golestan University of Medical Sciences

laleh.abbasi3@gmail.com+98 17 3242 1660

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026