Condition 1: Insulin-dependent diabetes mellitus. Condition 2: Non-insulin-dependent diabetes mellitus. Condition 3: Other specified diabetes mellitus. Condition 4: Unspecified diabetes mellitus. Insulin-dependent diabetes mellitus Non-insulin-dependent diabetes mellitus Other specified diabetes mellitus Unspecified diabetes mellitus
Conditions
Interventions
Dressing of ulcer with Autologous platelet rich plasma gel which is activated by cacl2 (2 ml/cm2 ) weekly up to full healing.
Rehabilitation
Dressing of ulcer with Autologous platelet rich plasma gel which is activated by cacl2 (2 ml/cm2 ) weekly up to full healing
Sponsors
Hematology, Oncology and Stem Cell Transplantation Reseach Center
Eligibility
Sex/Gender
All
Age
35 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients with chronic DFUs were enrolled in the study. Chronic DFU, considered as a wound in an extremity (mostly foot) of a known diabetic patient which has not decreased by 50% of the primary size in one month (Inclusion criteria). No other limitations such as age, sex, fasting blood sugar (FBS) or hemoglobin A1C (Hb A1C) levels were applied.Exclusion criteria included osteomyelitis, malignant arterial insufficiency, exposed bone in an ulcer, antibiotic resistance DFU, wounds with Charcot deformity, history of anti-proliferative medication or radiation in past 3 months, serum Hb<10 mg/dL, platelet count<103/µL and history of growth factor therapy within last 2 weeks.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ulcer size. Timepoint: weekly up to full healing. Method of measurement: Ruler. | — |
Secondary
| Measure | Time frame |
|---|---|
| Efficacy of platelet gel on prevention of foot amputation. Timepoint: mounthly after strat treatment. Method of measurement: visit by surgeon. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSaeed Mohammadi
Hematology, Oncology and Stem Cell Transplantation Resaerch Center
Outcome results
None listed