One-lung ventilation in thoracic surgery. Other specified respiratory disorders
Conditions
Interventions
Intervention 1: Control group: 100 µg/kg/min anesthetic propofol before thoracic surgery. Intervention 2: Intervention group: 0.01 µg/kg/min anesthetic isoflurane before thoracic surgery.
Treatment - Drugs
Control group: 100 µg/kg/min anesthetic propofol before thoracic surgery
Intervention group: 0.01 µg/kg/min anesthetic isoflurane before thoracic surgery
Sponsors
Vice Chancellor for Research, Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1) Aged 18-75 years; 2) sustaining ASA I and ASA II; and 3) consent to thoracic surgery according to OLV under investigation. Exclusion criteria: 1) Liver failure; 2)ischemia or heart valve disease; 3) history of anesthesia; 4) obstructive pulmonary disease with limitation in end-stage; 5) patients with OLV less than 30 minutes; 6) patients whose breath count reached 12 at the onset of anesthesia and before one-lung ventilation; and 7) patients with HRCT, PFT, and pathological lesions in the left lung.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of end-tidal carbon dioxide pressure. Timepoint: 10 and 20 minutes after intervention. Method of measurement: Capnography; mm Hg. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of arterial carbon dioxide pressure. Timepoint: 10 and 20 minutes after intervention. Method of measurement: Pulse oximetry; mm Hg. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShima Shebani
Mashhad University of Medical Sciences
Outcome results
None listed