COVID-19. COVID-19, virus identified
Conditions
Interventions
Intervention 1: Intervention group: Administration of 2 units of CP (Convalescent Plasma obtained from COVID-19 recovered people thorough plasmapheresis) (IV). Each unit of plasma that is collected fr
Sponsors
Semnan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
25 Years to 55 Years
Inclusion criteria
Inclusion criteria: (As a plasma donor): Complete resolution of COVID-19 disease symptoms at least 14 days prior to donation. (As a plasma donor): Donors do not have a history of blood or blood product transfusion (As a plasma donor): COVID-19 neutralizing antibody titers be greater than 1:320 (If possibly checked) (As a plasma donor): The donor's age be between 25 and 55 years old (As a plasma donor): Negative results for COVID-19 by PCR (As a plasma donor): Be in suitable general health condition for plasmapheresis (As a plasma recipient): Patients admitted to the ICU who is receipt of mechanical invasive or non-invasive ventilation, partial pressure of arterial oxygen to fraction of inspired oxygen ratio 65 mmHg (As a plasma recipient): Respiratory frequency = 30/min (As a plasma recipient): Laboratory-confirmed COVID-19 infection (by real time PCR).
Exclusion criteria
Exclusion criteria: (As a plasma recipient): Negative real-time PCR from respiratory secretions or blood within 48 h prior to CP transfusion (As a plasma recipient): History of allergic reaction to blood or plasma products (As a plasma recipient): Known IgA deficiency
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Checking the amount of ventilation. Timepoint: Before intervention, 30 minutes after each step of intervention and daily. Method of measurement: Artificial respirator or ventilator.;White blood cell count, CRP in patients with COVID-19. Timepoint: Every 24 hours (Before and after intervention). Method of measurement: Cell counter.;Percentage of T CD8 in peripheral blood. Timepoint: Before and after the intervention. Method of measurement: Evaluation of T CD8 percentage by Flow cytometry.;Percentage of T CD4 in peripheral blood. Timepoint: Before and after the intervention. Method of measurement: Evaluation of T CD4 percentage by Flow cytometry.;C-Reactive Protein (CRP) in patients with COVID-19. Timepoint: Every 24 hours (Before and after intervention). Method of measurement: Rapid test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactParviz Kokhaei
Semnan University of Medical Sciences
Outcome results
None listed