Preventive effect of Vitamin E in Taxol induced neuropathy

Evaluation of the Vitamin E effect in Taxol induced neuropathy reduction among patients with breast cancer

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015122725716N1

Enrollment

Registered

2016-11-04

Start date

2015-04-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neuropathy. Drug-induced polyneuropathy

Interventions

Intervention 1: Interventional Group: Treatment by Vitamin E 400 mg BID for 3 months. Intervention 2: Control Group: Intervention by placebo.

Treatment - Drugs

Placebo

Interventional Group: Treatment by Vitamin E 400 mg BID for 3 months

Control Group: Intervention by placebo

Eligibility

Sex/Gender

Female

Age

20 Years to 85 Years

Inclusion criteria

Inclusion criteria: inclusion criteria: patients with confirmed diagnosis of breast cancer ; Pateints under chemotherapy with Taxol Exclusion criteria: history of neuropathy( congenital or paraneoplastic); Systemic disorders(such as diabet and alcohol abuse) ' patients that have neuropathy before taxol treatment

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Motor and sensory nerve potenial. Timepoint: 3 months after intervention. Method of measurement: Electrodiagnostic.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Naser Mehraban

Ahvaz Jundishapur University of Medical Sciences

mehraban.n@ajums.ac.ir+61 33743009

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026