Ventilator-associated Pneumonia (VAP). Bacterial pneumonia, not elsewhere classified
Conditions
Interventions
Intervention 1: Intervention group: Received IV colistin (Colistimethate Sodium Injection, powder for solution parenteral 1000000 [IU] that belongs to Forest Laboratories Uk) based on Glomerular Filtr
AS colistin was prescribed only for a period of seven days (OMRON Mesh Nebulizer Model NE-U22). To prevent bronchospasm caused by nebulized colistin, patients were premedicated with salbutamol prior t
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Age above 18 years Antibiogram of positive culture that is sensitive to Colistin and resistant to all other antibiotics The new continuous pulmonary secretions based on lung radiography among patients who are received mechanical ventilation for at least 48 hours Fever above 38ºC without any specific reason White Blood Cell number more than 12000 cells or less than 4000 cells in each milliliter Purulent tracheal secretions
Exclusion criteria
Exclusion criteria: Pregnancy Breastfeeding Septic shock
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The correlation between antibiotic therapy initiation and the time of negative procalcitonin (PCT) test. Timepoint: Days of 0, 3, 5, 7 after antibiotic initiation. Method of measurement: Immunochromatographic test (PCT-Q).;The correlation between antibiotic therapy initiation and the time of negative sputum culture. Timepoint: Days of 0, 4, 7 after antibiotic initiation. Method of measurement: Sputum culture. | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of ICU stay. Timepoint: Daily. Method of measurement: By the date of admission and discharge mentioned in Clinical records.;Time of fever discontinuation. Timepoint: Every other day. Method of measurement: Thermometer.;The correlation between antibiotic therapy initiation and the reduction of WBC. Timepoint: Every other day. Method of measurement: Hematologic test.;The correlation between antibiotic therapy initiation and improvement of PaO2/FiO2. Timepoint: Every other day. Method of measurement: By arterial and venous blood gasses (ABG and VBG).;Chest X-Ray changes. Timepoint: Every other day. Method of measurement: By chest x-ray radiography.;Improvement of Clinical Pulmonary Infection Score (CPIS). Timepoint: Every other day. Method of measurement: BY CPIS score.;All the adverse effects associated with the use of colistin including bronchospasm, neurotoxicity, and hypersensitivity reactions. Timepoint: Daily. Method of measurement: Clinical records. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFaezeh Feizabadi
Shahid Beheshti University of Medical Sciences
Outcome results
None listed