Evaluating the effects of saffron on fatigue symptoms in patients with chronic obstructive pulmonary disease

Evaluating the Effects of Crocus Sativus herbal product on Chronic Fatigue Syndrome in Patients with Chronic Obstructive Pulmonary Disease

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20151227025726N34

Enrollment

Registered

2023-10-09

Start date

2023-10-12

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic obstructive pulmonary disease. Other chronic obstructive pulmonary disease

Interventions

Intervention 1: Intervention group: Patients in the intervention group received capsules containing 30 mg of dry saffron extract (Duralife® prepared by Faran Shimi Company) twice a day for two months.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: People over 18 years old with chronic obstructive pulmonary disease and chronic fatigue syndrome at the same time

Exclusion criteria

Exclusion criteria: Pregnancy and breastfeeding suffering from Rheumatoid diseases and osteoarthritis Having electrolyte disorders Suffering from adrenal insufficiency Suffering from obstructive sleep apnea disease Suffering from other lung diseases such as asthma, lung fibrosis Patient with acute exacerbation of chronic obstructive pulmonary disease in the last month History of central nervous system disease (stroke, epilepsy, tumor, history of neurosurgery) Taking any sleep-sedative drugs, stimulant drugs, antidepressant and anticoagulant drugs Allergy to saffron or formulation components Having any known Nervous and mental illness

Design outcomes

Primary

Measure	Time frame
Investigating the effect of herbal product containing crocus sativus on chronic fatigue syndrome in patients with COPD. Timepoint: The beginning of the study, the end of the first month and the end of the second month. Method of measurement: Manchester COPD Fatigue Scale (MCFS) and Chronic Respiratory Questionnaire (CRQ) questionnaire.	—

Secondary

Measure	Time frame
Investigating the effect of crocus sativus herbal product on the quality of life of patients with chronic obstructive pulmonary disease. Timepoint: The beginning of the study, the end of the first and second month. Method of measurement: St. George's Respiratory Questionnaire (SGRQ) questionnaire.;Investigating the effect of crocus sativus herbal product on the severity of shortness of breath in patients with COPD. Timepoint: The beginning of the study, the end of the first and second month. Method of measurement: Modified Medical Research Council (mMRC) and Body mass index, airflow Obstruction, Dyspnea, and Exercise capacity (BODE Index) score.	—

Measure

Time frame

Investigating the effect of crocus sativus herbal product on the quality of life of patients with chronic obstructive pulmonary disease. Timepoint: The beginning of the study, the end of the first and second month. Method of measurement: St. George's Respiratory Questionnaire (SGRQ) questionnaire.;Investigating the effect of crocus sativus herbal product on the severity of shortness of breath in patients with COPD. Timepoint: The beginning of the study, the end of the first and second month. Method of measurement: Modified Medical Research Council (mMRC) and Body mass index, airflow Obstruction, Dyspnea, and Exercise capacity (BODE Index) score.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactReza Mahmoodian

Shahid Beheshti University of Medical Sciences

mahmoodian.reza@yahoo.com+98 21 2712 2227

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026