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Evaluation of the Effects of Noscapine on the Treatment of Patients with COVID-19

Evaluation of the Effects of Noscapine on the Treatment of Cough in COVID-19 Outpatients

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20151227025726N31
Enrollment
100
Registered
2022-06-18
Start date
2022-06-18
Completion date
Unknown
Last updated
2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19 pneumonia. COVID-19, virus identified

Interventions

Intervention 1: Intervention group: Patients receive Noscapine Syrup (Noscough®) 20 cc every 6 hours for 5 days. Intervention 2: Control group: Patients receive 7 cc diphenhydramine every 8 hours.

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: People over 18 years old Patient with cough and positive RT-PCR for COVID-19 and candidate for outpatient treatment The onset of illness equal to/less than 5 days

Exclusion criteria

Exclusion criteria: Pregnancy Breastfeeding Allergy to noscapine, morphine or any of the components of the formulation History of seizure Diarrhea Diabetes Consumption of warfarin, benzodiazepines, opioid agonists Getting antitussive drugs

Design outcomes

Primary

MeasureTime frame
Time required to respond to treatment. Timepoint: Daily until discharge. Method of measurement: VAS scale.;Time required to resolve cough. Timepoint: Daily until discharge. Method of measurement: Patient history.;Intensity of cough. Timepoint: Daily until discharge. Method of measurement: CSS score.

Secondary

MeasureTime frame
Quality of Life. Timepoint: Before the start of the study and at the end of the study. Method of measurement: CQLQ questionnaire.;Blood oxygen level. Timepoint: Before the start of the study and at the end of the study. Method of measurement: Pulse oximeter.;Shortness of breath. Timepoint: Before the start of the study and at the end of the study. Method of measurement: Patient history.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSahar Yousefian

Shahid Beheshti University of Medical Sciences

saahar26@yahoo.com+98 21 2712 2227

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026