COVID-19 pneumonia. COVID-19
Conditions
Interventions
Intervention group: Dilute 400 mg of ACTEMRA (Tocilizumab) in at least 100 ml of normal saline 0.9 and give it slowly intravenously over at least one hour. The drug should be given at 2 to 8 ° C befor
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients between 18 and 70 years old Laboratory confirmed COVID-19 with RT-PCR Be in severe or critical stage of the disease Have interleukin-6 levels above 15 picogram per milliliter or CRP above 100 miligram per liter
Exclusion criteria
Exclusion criteria: Acute or chronic renal failure (Increase in creatinine by more than 3.0 in the last 48 hours or GFR less than 30 mL/min) Liver failure (more than 5-fold increase in liver enzymes in asymptomatic patients or more than 3-fold increase in liver enzymes in symptomatic patients or Child Pugh C, D) Hypersensitivity reaction during tocilizumbe injection with severe extrusion and symptoms of anaphylactic shock Mild stage of the disease Pregnant and lactating patients Patients with platelets less than 100,000 or ANC less than 5 Patients with Latent TB or Active TB or any active infection History of active gastric ulcer Patients with positive viral marker
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality. Timepoint: Days 7, 14 and 21 of hospitalization. Method of measurement: Medical record.;Need for intubation. Timepoint: Daily until discharge. Method of measurement: Medical record.;Lung radiological changes. Timepoint: Before receiving tocilizumab and after discharge. Method of measurement: Computed tomography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of days admitted to critical care unit. Timepoint: Daily until discharge. Method of measurement: Medical record.;Length of hospital stay. Timepoint: Daily until discharge. Method of measurement: Medical record. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSahar Yousefian
Shahid Beheshti University of Medical Sciences
Outcome results
None listed