COVID-19 pneumonia. COVID-19, virus identified
Conditions
Interventions
Intervention 1: Intervention group: 60 patients will receive remdesivir (Veklury) 200 mg day one then 100 mg day 2 to 5. Intervention 2: Intervention group: 60 patients will receive generic (Ronak Dar
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Patients above 18 years old Confirmed COVID-19 (Corona Virus Disease-19) with RT-PCR (Real-Time Polymerase Chain Reaction) Lung CT scan confirming lung involvement Hospitalized with SaO2/SPO2=94% in room air or having Pa02/Fi02 <300mgHg Becoming symptomatic within the past two weeks
Exclusion criteria
Exclusion criteria: Severe liver disease (Child Pugh score = C, AST>10 times upper limit) Pregnancy Breastfeeding Sever renal failure ( estimated glomerular filtration rate =30 mL/min/1.73 m2) or receiving dialysis Drug interactions (Methimazole, chloroquine, hydroxychloroquine)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to clinical improvement. Timepoint: Daily until day 5. Method of measurement: Six-category ordinal scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of hospital stay. Timepoint: Daily until discharge. Method of measurement: Medical record.;Number of days admitted to critical care unit. Timepoint: Daily until discharge. Method of measurement: Medical record.;Length of time in which patient needs oxygen therapy. Timepoint: Daily until discharge. Method of measurement: Medical record.;Length of time in which patient needs mechanical ventilation. Timepoint: Daily until discharge. Method of measurement: Medical record.;Mortality. Timepoint: Daily until discharge. Method of measurement: Medical record. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHamidreza Jamaati
Shahid Beheshti University of Medical Sciences
Outcome results
None listed