Evaluation of the Effect of Calcitriol on the Percutaneous Coronary Intervention

Evaluation of the Effects of Calcitriol on Ischemia-reperfusion Injury and Inflammatory Biomarkers in Patients Undergoing Percutaneous Coronary Intervention (PCI)

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20151227025726N10

Enrollment

Registered

2018-11-30

Start date

2017-07-23

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Percutaneous coronary intervention (PCI). Atherosclerotic heart disease of native coronary artery with unstable angina pectoris

Interventions

Intervention 1: Intervention group: Administration of 3 µg of injectable calcitriol intravenous, 3 hours before performing PCI. Intervention 2: Control group: No intervention was made.

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: Patients referring to Shahid Modarres hospital cath lab Patients more than 18 years old Patients who are candidated for elective PCI surgery

Exclusion criteria

Exclusion criteria: Serum creatinine level more than 2 mg/dL Active metabolic bone disease Vitamin D supplementation receivement Consuming anti-inflammatory drugs (except aspirin and statin) Severe hepatic disease (Child-paugh C) Ejection fraction less than 30% Contraindications or hypersensitivity to calcitriol

Design outcomes

Primary

Measure	Time frame
Change in CK-MB serum level. Timepoint: Before surgery and 24 hours after percutaneous coronary intervention. Method of measurement: Laboratory kit measuring serum level of CK-MB.;Change in Interleukin-6 serum level. Timepoint: Before surgery and 24 hours after percutaneous coronary intervention. Method of measurement: Laboratory kit measuring serum level of interleukin 6.;Change in total high sensitivity CRP serum level. Timepoint: Before surgery and 24 hours after percutaneous coronary intervention. Method of measurement: Laboratory kit measuring serum level of high sensitivity CRP.;Change in cardiac Troponin I serum level. Timepoint: Before surgery and 24 hours after percutaneous coronary intervention. Method of measurement: Laboratory kit measuring serum level of cardiac Troponin I.	—

Measure

Time frame

Change in CK-MB serum level. Timepoint: Before surgery and 24 hours after percutaneous coronary intervention. Method of measurement: Laboratory kit measuring serum level of CK-MB.;Change in Interleukin-6 serum level. Timepoint: Before surgery and 24 hours after percutaneous coronary intervention. Method of measurement: Laboratory kit measuring serum level of interleukin 6.;Change in total high sensitivity CRP serum level. Timepoint: Before surgery and 24 hours after percutaneous coronary intervention. Method of measurement: Laboratory kit measuring serum level of high sensitivity CRP.;Change in cardiac Troponin I serum level. Timepoint: Before surgery and 24 hours after percutaneous coronary intervention. Method of measurement: Laboratory kit measuring serum level of cardiac Troponin I.

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Secondary

Measure	Time frame
Myocardial infarction (MI). Timepoint: 90 to 100 days after intervention. Method of measurement: Check patient records and verbal interview at clinic.;The need for Percutaneous Coronary Intervention (PCI). Timepoint: 90 to 100 days after intervention. Method of measurement: Check patient records and verbal interview at clinic.;The need for Coronary Artery Bypass Graft (CABG). Timepoint: 90 to 100 days after intervention. Method of measurement: Check patient records and verbal interview at clinic.;All-cause death. Timepoint: 90 to 100 days after intervention. Method of measurement: Check patient records and telephone interview.	—

Measure

Time frame

Myocardial infarction (MI). Timepoint: 90 to 100 days after intervention. Method of measurement: Check patient records and verbal interview at clinic.;The need for Percutaneous Coronary Intervention (PCI). Timepoint: 90 to 100 days after intervention. Method of measurement: Check patient records and verbal interview at clinic.;The need for Coronary Artery Bypass Graft (CABG). Timepoint: 90 to 100 days after intervention. Method of measurement: Check patient records and verbal interview at clinic.;All-cause death. Timepoint: 90 to 100 days after intervention. Method of measurement: Check patient records and telephone interview.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Mahdi Hashempour

Shahid Beheshti University of Medical Sciences

hashempourmm@sbmu.ac.ir+98 21 8820 0118

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026