Comparison the efficacy of misoprostol and oxytocin for induction of labor on fetal cardiotocogram in pregnancies with GA >= 41w

The efficacy of misoprostol and oxytocin for induction of labor

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015122425648N2

Enrollment

Registered

2016-02-21

Start date

2016-02-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prolonged pregnancy. Prolonged pregnancy

Interventions

Intervention 1: Intervention 1: 50 µg sublingual misoprostol (a quarter of tablet) will be administered, every 4 hours up to 4 doses and placebo. Intervention 2: Intervention 2: oxytocin infusion wil

Treatment - Drugs

Intervention 1: 50 µg sublingual misoprostol (a quarter of tablet) will be administered, every 4 hours up to 4 doses and placebo

Intervention 2: oxytocin infusion will be administered 2 mIU/min infusion and increase by 2 mIU/min in every 15 minutes and placebo

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Inclusion criteria are: mothers desire to have vaginal delivery, gestational age of 41 weeks and above, having Bishop score below 5, normal non-stress test (NST) at birth, normal oxytocin challenge test (OCT), lack of uterine contractions. Exclusion criteria included: contraindication of misoprostol or oxytocin, fetal macrosomia, polyhydramnios, placenta previa or abruption, meconial, vaginal bleeding, intrauterine growth restriction, non-cephalic presentation, and narrow pelvis. Exclusion criteria are: contraindication of misoprostol or oxytocin, fetal macrosomia, polyhydramnios, placenta previa or abruption, meconial, vaginal bleeding, intrauterine growth restriction, non-cephalic presentation, and narrow pelvis. Then need for cesarean section and fetal heart rate changes will be compared between two groups.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Fetal heart beat changes. Timepoint: Every Half an hour. Method of measurement: Non-stress test.;Need to perform cesarean section. Timepoint: Every half hour. Method of measurement: Clinical.	—

Secondary

Measure	Time frame
APGAR. Timepoint: First and Fifth minutes. Method of measurement: Clinical.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasoumeh Mirteimouri

Mashhad University of Medical Sciences

rahmanish3@mums.ac.ir+98 51 3623 1061

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Mar 12, 2026