Traumatic brain injury. Diffuse traumatic brain injury
Conditions
Interventions
Intervention 1: Intervention group: Curcumin capsule containing 500 mg of curcumin and 5 mg of piperine (manufactured by Sabinsa Company), 1 capsule every 24 hours orally. Intervention 2: Control grou
Sponsors
Tehran University of Medical Sciences
Anesthesiology, critical care and pain management research center
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: The age of the patient is between 18 and 85 years; The reason for admission to the intensive care unit is head trauma; The patient or his first degree relatives have signed the consent form knowingly and freely; Glasgow coma scale is 8 and above; Less than 48 hours have passed since the loss of consciousness secondary to traumatic brain injury; There is no prohibition to receive oral medications.
Exclusion criteria
Exclusion criteria: Pregnancy; Lactation; Not being hemodynamically and metabolically stable and needing to receive vasoactive drugs; History of any type of disease or autoimmune disorders; History of chemotherapy and radiotherapy in the past month; History of any liver failure; Active bleeding; History of known Curcumin allergy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SOFA score. Timepoint: Days 0 and 7. Method of measurement: SOFA score (The Sequential Organ Failure Assessment Score) calculation.;Glasgow coma scale (GCS) score. Timepoint: Days 0 and 7. Method of measurement: Glasgow coma scale (GCS) score calculation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactParisa Kianpour
Tehran University of Medical Sciences
Outcome results
None listed