Acute kidney injury. Acute kidney failure
Conditions
Interventions
Intervention 1: Intervention group: Black Seed Oil Soft Capsule of Barij Essence, 1000 mg, to be taken orally once daily for 5 days. Intervention 2: Control group: Placebo capsules with an identical a
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Written, voluntary informed consent must be obtained from the patient or their legal representative. The patient must have developed sepsis based on the following criteria: A minimum increase of two points in the SOFA score compared to baseline, along with a confirmed infection. The patient must meet the RIFLE criteria for AKI: Serum creatinine must have increased by at least 1.5 times from baseline; or Urine output must have decreased to less than 0.5 ml/kg/h.
Exclusion criteria
Exclusion criteria: A documented history of allergy to the family of Nigella sativa (black seed) Chronic kidney disease characterized by a creatinine clearance (ClCr) of less than 15 ml/min Pregnant or breastfeeding Death or transfer of the patient to another healthcare facility within the first 72 hours of study enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of the Effect of Thymoquinone on SrCr in sepsis associated Acute Kidney Injury. Timepoint: Prior and post intervention (day 1 and 5). Method of measurement: Blood test.;Evaluation of the Effect of Thymoquinone on BUN in sepsis associated Acute Kidney Injury. Timepoint: Prior and post intervention (day 1 and 5). Method of measurement: Blood test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of the effect of Thymoquinone on NGAL in sepsis associated Acute Kidney Injury. Timepoint: Prior and post intervention (day 1 and 5). Method of measurement: ELISA kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactParisa Kianpour
Tehran University of Medical Sciences
Outcome results
None listed