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Study of the efficacy of Indigo Naturalis ointment in the treatment of Plaque – type Psoriasis and comparison between ointments made of two different Chinese and Iranian herbs and betamethasone ointment

Study of the efficacy of Indigo Naturalis ointment in the treatment of Plaque – type Psoriasis and comparison between ointments made of two different Chinese and Iranian herbs and betamethasone ointment

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT201512157265N5
Enrollment
30
Registered
2016-04-16
Start date
2015-12-23
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Psoriasis. Psoriasis

Interventions

Intervention 1: Intervention group 1: Treatment by Chinese ointment of Indigo Naturalis containing 20% Indigo Naturalis (produced by Tongrentang Pharmaceutical company, Beijing, China) and 80% vehicl
topical treatment twice a day for 8 weeks. Intervention 2: Intervention group 2: Treatment by Iranian ointment containing 20% Indigofera tinctoria extract (Plant powder with 70% ethanol) and 80% vehic
topical treatment twice a day for 8 weeks. Intervention 3: Control group: Topical treatment by betamethasone ointment 0.1%+ Edible dyes twice a day for 8 weeks.
Treatment - Drugs
Intervention group 1: Treatment by Chinese ointment of Indigo Naturalis containing 20% Indigo Naturalis (produced by Tongrentang Pharmaceutical company, Beijing, China) and 80% vehicle (25% Vaseline,
topical treatment twice a day for 8 weeks
Intervention group 2: Treatment by Iranian ointment containing 20% Indigofera tinctoria extract (Plant powder with 70% ethanol) and 80% vehicle (25% Vaseline, 30% yellow wax, and 45% olive oil)
Control group: Topical treatment by betamethasone ointment 0.1%+ Edible dyes twice a day for 8 weeks

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
12 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion criteria: age 12 years old and more; chronic plaque psoriasis; lesion extension less than 10% body surface area, bilateral lesions on the extremities; do not have another important diseases, especially liver and kidney diseases. Exclusion criteria: use of topical drugs in the last 14 days or systemic drug in the last 30 days; pregnancy or a plan to get pregnant, breast-feeding; people with hepatitis B and C and HIV positive patients; allergy to herbal medicines; abnormal laboratory findings; use of topical or systemic drugs that have a positive or negative effect on progression of the disease.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
PASI score. Timepoint: Before treatment, week 2, week 4, week 6, week 8. Method of measurement: Comparison between ointments made of two different Chinese and Iranian herbs and betamethasone ointment.—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Hoda Azizi

Department of Chinese and complementary medicine, Mashhad University of Medical Sciences

azizih@mums.ac.ir+98 51 3855 2188

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026