Lichen planus. Lichen planus
Conditions
Interventions
Intervention 1: Intervention group: curcumin tablets at a dose of 2000 mg/day for a period of 4 weeks. Intervention 2: Control group: placebo for a period of 4 weeks.
Treatment - Drugs
Placebo
Intervention group: curcumin tablets at a dose of 2000 mg/day for a period of 4 weeks
Control group: placebo for a period of 4 weeks
Sponsors
Vice chancellor for research, Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with clinical signs of erosive and atrophic OLP confirmed by clinical or histopathological examination were included in our study. The exclusion criteria: pregnancy; lactation; current use of anticoagulants or antiplatelet agents; currant orthodontic treatment; history of gastric ulcers; duodenal ulcers; gallstones; hepatic diseases; any existing malignancy or viral infection in mouth; receiving any topical treatment for OLP in the past 2 weeks or any systemic treatment for OLP in the past 4 weeks; use of azathioprine, cyclosporine or receiving PUVA, UVA or UVB in the last month; a history of allergy to corticosteroids or curcumin.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lichen planus improvement. Timepoint: On days 14 and 28. Method of measurement: Thongprasom index. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain and burning sensation. Timepoint: On days 14 and 28. Method of measurement: Visual analogue scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Maryam Amirchakhmaghi
Mashhad Dental School
Outcome results
None listed