The effect of high-intensity interval training and Nasturtium officinale on inflammatory markers and vasodilation and body composition of patients with subclinical hypothyroidism

Interactive effect of 8 weeks of Nasturtium officinale and high-intensity interval training on gp91 phox, lipid profile, hs-CRP, FABP4, adrenomedulin, thyroid hormones and body composition in patients with subclinical hypothyroidism

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20151214025524N2

Enrollment

Registered

2022-04-19

Start date

2022-05-05

Completion date

Unknown

Last updated

2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subclinical hypothyroidism. Subclinical iodine-deficiency hypothyroidism

Interventions

Intervention 1: Intervention group:This group performs high-intensity interval training (80 to 90% of maximum heart rate) on the treadmill for eight weeks, 3 sessions per week. Intervention 2: Interve

Eligibility

Sex/Gender

All

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Hypothyroid patients who are diagnosed with endocrinologist and with 10> TSH>2 age beween 16 and 65 years Written consent of the patient to participate in the study Lack of heart disease, coagulation disorders, autoimmune disorders No pituitary and hypothalamic problems, kidney disease, malignancy and other thyroid disorders No pregnancy or breastfeeding

Exclusion criteria

Exclusion criteria: Taking herbal supplements not attending regular exercise

Design outcomes

Primary

Measure	Time frame
Gp91 phox. Timepoint: Beginning and end of the study after 8 weeks. Method of measurement: ELISA.;Hs-CRP. Timepoint: Beginning and end of the study after 8 weeks. Method of measurement: ELISA.;FABP4. Timepoint: Beginning and end of the study after 8 weeks. Method of measurement: ELISA.;Adrenomedullin. Timepoint: Beginning and end of the study after 8 weeks. Method of measurement: ELISA.	—

Secondary

Measure	Time frame
Lipid profiles. Timepoint: Beginning and end of 8 weeks. Method of measurement: Enzymatic method.;Thyroid hormones. Timepoint: Beginning and end of 8 weeks. Method of measurement: Thyroid hormones, including thyroid stimulating hormone, triiodothyronine and thyroxine, will be measured by ELISA.;Body composition. Timepoint: Beginning and end of 8 weeks. Method of measurement: Body composition will be measured by bioimpedance (BIA).	—

Measure

Time frame

Lipid profiles. Timepoint: Beginning and end of 8 weeks. Method of measurement: Enzymatic method.;Thyroid hormones. Timepoint: Beginning and end of 8 weeks. Method of measurement: Thyroid hormones, including thyroid stimulating hormone, triiodothyronine and thyroxine, will be measured by ELISA.;Body composition. Timepoint: Beginning and end of 8 weeks. Method of measurement: Body composition will be measured by bioimpedance (BIA).

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Countries

Iran (Islamic Republic of)

Contacts

Public Contactelham ghasemi

University of Sistan and Baluchestan

elhamghasemi@uoz.ac.ir+98 54 3113 2674

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026