Effect of green cardamom on improvement of non-alcoholic fatty liver disease

Conditions

Condition 1: Nonalcoholic fatty liver disease. Condition 2: Overweight or Obesity. Nonalcoholic fatty liver disease overweight or obesity

Milad Daneshi‐Maskooni, Seyed Ali Keshavarz, Mostafa Qorbani, Siavash Mansouri, Seyed Moayed Alavian et al. (8 authors)

BMC Complementary and Alternative Medicine2019-03-1253 citations

10.1186/s12906-019-2465-0

Green cardamom increases Sirtuin-1 and reduces inflammation in overweight or obese patients with non-alcoholic fatty liver disease: a double-blind randomized placebo-controlled clinical trial.

Daneshi-Maskooni M, Keshavarz SA, Qorbani M, Mansouri S, Alavian SM, Badri-Fariman M, Jazayeri-Tehrani SA, Sotoudeh G.

2018-09-2529 citations

10.1186/s12986-018-0297-4

The effects of green cardamom on blood glucose indices, lipids, inflammatory factors, paraxonase-1, sirtuin-1, and irisin in patients with nonalcoholic fatty liver disease and obesity: study protocol for a randomized controlled trial

Milad Daneshi‐Maskooni, Seyed Ali Keshavarz, Siavash Mansouri, Mostafa Qorbani, Seyed Moayed Alavian et al. (8 authors)

Trials2017-06-0735 citations

10.1186/s13063-017-1979-3

Interventions

Intervention 1: Green cardamom supplementation, 3 gram/day, 3 capsules (1gram)/day with food, for 3 months. Intervention 2: Placebo (bread crumbs) supplementation, 3 gram/day, 3 capsules (1gram)/day w

Treatment - Other

Placebo

Green cardamom supplementation, 3 gram/day, 3 capsules (1gram)/day with food, for 3 months

Placebo (bread crumbs) supplementation, 3 gram/day, 3 capsules (1gram)/day with food, for 3 months

Eligibility

Sex/Gender

All

Age

30 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: non-alcohilic fatty liver disease diagnosed by a radiologist and hepatologist using ultrasonography into one of three categories (mild, moderate or severe degree); age 30–60 years old; overwight or obesity (25=BMI90/140 mmHg); any diagnosed malignancy; breast-feeding, pregnancy and or plan for pregnancy in the next 3 months; professional athlete or regular exercise; treatment with statins, antihypertensive and ursodeoxy colic acid, probiotics and multivitamin-mineral and antioxidant supplements during the three months prior to the intervention; surgery for weight loss in the last year and weight loss program for the past three month; different drugs that interact with cardamom, including aspirin, anticoagulants (warfarin, heparin) and antiplatelet (clopidogrel), non-steroidal anti-inflammatory (ibuprofen or naproxen), blood pressure-lowering drugs, CNS depressants (benzodiazepines such as lorazepam or diazepam, barbiturates such as phenobarbital, narcotics such as codeine, some antidepressants and alcohol), anesthetics, antibiotics, anti-cancer agents, anti-cholinergics, anti-fungals, cyproheptadine, diuretics (loop), estrogen, indomethacin, muscarinic agents, pain relievers and prednisolone; taking a multivitamin-mineral and or antioxidants supplement at least twice a week during study; not taking more than 10% of prescription supplements.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Serum Irisin. Timepoint: Before and after intervention. Method of measurement: Elisa kit.;Serum Sirtuin1. Timepoint: Before and after intervention. Method of measurement: Elisa kit.;Serum Paraxonase-1. Timepoint: Before and after intervention. Method of measurement: Elisa kit.	—

Secondary

Measure	Time frame
Serum TNF-a, IL-6 and hs-CRP. Timepoint: Before and after intervention. Method of measurement: Elisa Kit.;FBS, FPI. Timepoint: Before and after intervention. Method of measurement: Kit.;SBP, DBP. Timepoint: Before and after intervention. Method of measurement: mmhg by mercury manometer?.;Serum TG, TC, LDL and HDL. Timepoint: Before and after intervention. Method of measurement: Kit.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactGity Sotoudeh

Tehran University of Medical Sciences

gsotoodeh@yahoo.com+98 21 8895 5742

Outcome results

None listed