Assessment of intermittent and continuous infusion dose of N-acetylcysteine on oxidative stress levels and total antioxidant capacity of the body in septic patients admitted to the ICU

Clinical trial assessment of intermittent and continuous infusion dose of N-acetylcysteine on oxidative stress levels and total antioxidant capacity of the body in septic patients admitted to the ICU

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201512118384N6

Enrollment

Registered

2017-04-07

Start date

2014-11-06

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis. Sepsis, unspecified

Interventions

Intervention 1: The first Intervention group received 25 mg/kg intravenous bolus on the N-acetyl cysteine (NAC) at the beginning and then 25 mg/kg every 8 hours for 24 hours (total 100 mg/kg during t

Treatment - Drugs

The first Intervention group received 25 mg/kg intravenous bolus on the N-acetyl cysteine (NAC) at the beginning and then 25 mg/kg every 8 hours for 24 hours (total 100 mg/kg during the 24 hours

The second Intervention group received 25 mg/kg intravenous bolus on the N-acetyl cysteine (NAC) at the beginning and then 75 mg/kg intravenous NAC as a continuous infusion over 24 hours (total 100 mg

Control group: received 100 mg/kg saline

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients with systemic inflammatory response syndrome, infection (sepsis) admitted to the ICU Exclusion criteria: lack of patient consent to participate in the study; Taking any supplements such as vitamins with antioxidant properties known as C, E, A, trace elements zinc, manganese, selenium, and NAC before entering the study; NAC drug contraindications for any reason

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Total antioxidant capacity. Timepoint: Baseline and 24 hours after completion of the study or the same time. Method of measurement: Using Cayman kits Company.;Level of Lipid peroxide serum. Timepoint: Baseline and 24 hours after completion of the study or the same time. Method of measurement: Using Cayman kits Company.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Peivandi

Mashhad University of Medical Sciences

PeivandiA@mums.ac.ir+98 51 3802 2711

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026