Brain Injury. Intracranial injury
Conditions
Interventions
Intervention 1: lettuce extracts will be administered 250 ml twice daily for 7 days to intervention group. Intervention 2: The control group will receive placebo twice daily for 7 days.
Treatment - Drugs
lettuce extracts will be administered 250 ml twice daily for 7 days to intervention group.
The control group will receive placebo twice daily for 7 days.
Sponsors
Vice- Chancellor for Research of Zanjan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: Age older than 18 years; Patients with brain injury alone; Admitted in the ICU less than 24 hours; Not receiving immunosuppressive or NSAID; No neurological or psychological diseases; No history of head trauma in the past 4 weeks; Glasgow Coma Scale score Between 5-8; Ability enteral nutrition within 48 hours of admission; The absence of signs of infection or pneumonia; patient's Relatives satisfaction to participate in research exclusion criteria: Patients who die before 48 hours after admission in the ICU; Patients with contraindications to any cause to enteral feeding during the study; Unwillingness of patient's Relatives to participate in research; Any sensitivity to lettuce; Need to take immunosuppressive or NSAID during hospitalization
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality. Timepoint: End of the study. Method of measurement: Records. | — |
Secondary
| Measure | Time frame |
|---|---|
| IL6. Timepoint: first day , 72 h after brain injury. Method of measurement: kit.;CRP. Timepoint: first day , 72 h after brain injury. Method of measurement: kit.;Start time of connecting to the ventilator. Timepoint: The last day of admission in the ICU. Method of measurement: Records.;Connection to ventilator days. Timepoint: The last day of admission in the ICU. Method of measurement: Records.;Length of ICU stay. Timepoint: The last day of admission in the ICU. Method of measurement: Records.;Start time of administration of vasopressor. Timepoint: The last day of admission in the ICU. Method of measurement: Records.;The number of days that the patients need vasopressor. Timepoint: The last day of admission in the ICU. Method of measurement: Records.;GCS at the discharge. Timepoint: The last day of admission in the ICU. Method of measurement: Records.;Ventilator associated pneumonia. Timepoint: Days 3 and 6. Method of measurement: Clinical Pulmonary Infection Score. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Hamid Khaleghi
Zanjan University of Medical Sciences
Outcome results
None listed