Comparison of the effect of local pressure and topical anesthesia with lidocaine /prilocaine cream (EMLA) on pain during infiltration of maxillary canine teeth: Randomized clinical trial

Comparison of the effect of local pressure and topical anesthesia with lidocaine/ prilocaine cream (EMLA) on pain during infiltration of maxillary canine teeth: Randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015120925456N1

Enrollment

140

Registered

2016-03-03

Start date

2015-10-18

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

local anesthesia. Codes for special purposes

Interventions

Intervention 1: This is a split mouth, randomized clinical trial study. Intervention group 1: Before administration of anesthesia, finger pressure would be applied on the alveolar mucosa at injection

Treatment - Drugs

Placebo

This is a split mouth, randomized clinical trial study. Intervention group 1: Before administration of anesthesia, finger pressure would be applied on the alveolar mucosa at injection site in one side

In the opposite side of intervention group 1, finger pressure will be applied on the tooth crown.

Intervention group 2: Before administration of anesthesia, 5% EMLA cream would be applied on the injection site(experimental side).

In the opposite side of intervention group 2, placebo will be applied at the injection site.

Intervention group3: Before administration of anesthesia, finger pressure would be applied on the alveolar mucosa at injection site on one side and on the opposite side 5% EMLA cream would be used.

Intervention group 4: Before administration of anesthesia, 5% EMLA cream would be applied on the injection site and on the opposite side 20% benzocaine gel would be used.

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Healthy adults with the age 18-55 years old; intact or with minimal caries and restoration maxillary canine teeth with normal view in periapical radiography; normal probing depth; no sensitivity to palpation and percussion; no consumption of painkillers,analgesics and anxiolytics drugs in recent 2 weeks; no allergy to anesthetic material and no medical history; clinical diagnosis of intact tooth would be confirmed by response to electric pulp tester(PARKELL,PT-20,made in USA) and normal response(short momentary answer). Exclusion criteria:Systemic disease and/or maxillary sinusitis; patients with tooth pain at the time of study; unstable heart disease; allergy to anesthesia material of lidocaine 2% with 1/80000 epinephrine or latex or lidocaine or prilocaine gels; facial or or oral parasthesia; consumption of painkillers,analgesics and anxiolytics drugs in 2 weeks before treatment; presence of periapical radiolucency; pregnancy; breast-feeding; non-repairable tooth and presence of crown

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain intensity. Timepoint: immediately after injection. Method of measurement: visual analoge scale.	—

Secondary

Measure	Time frame
Hematoma. Timepoint: 24 hours after treatment. Method of measurement: visual observation(objective).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmir Ardalan Abdollahi

Department of Endodontics, Faculty of Dentistry

ardalan_2000a@yahoo.com; abdollahiardalan@gmail.com+98 41 3330 8174

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026