Non alcoholic fatty liver. Non alcoholic fatty liver disease
Conditions
Interventions
Intervention 1: Intervention group : 700 mg (two 350 mg cap ) Shirazi thyme powder bid for 90 days. Intervention 2: Control group : 700 mg (two cap 350 mg ) wheat powder bid for 90 days.
Treatment - Drugs
Placebo
Intervention group : 700 mg (two 350 mg cap ) Shirazi thyme powder bid for 90 days
Control group : 700 mg (two cap 350 mg ) wheat powder bid for 90 days
Sponsors
Vice chancellor for research, Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: signed informed consent; age between 20 to 65 years old; BMI : 18 - 35; evidence of fatty liver in sonography; ALT equal or more than 45 in male and equal or more than 29 in female. Exclusion criteria: pregnancy; lactation; alcohol consumption; diabetes mellitus; history of allergic reaction to Thyme; acute or chronic hepatic disease; treated or untreated malignancy; consumption of hepatotoxic drugs during six months ago or less; consumption of drugs with effect on the biochemical markers of this study during three months ago or less; hyper or hypothyroidism; renal insufficiency (Cr > 1.5 ).
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alaninaminotransferase. Timepoint: Before intervention and three months after intervention. Method of measurement: Blood sampling.;Grade of fatty liver. Timepoint: Before intervention and three months after intervention. Method of measurement: Ultrasonography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure. Timepoint: Before intervention and three months after intervention. Method of measurement: By manometer according to mmHg.;Fasting blood sugar. Timepoint: Before intervention and three months after intervention. Method of measurement: Blood sampling.;Aspartateaminotransferase. Timepoint: Before intervention and three months after intervention. Method of measurement: Blood sampling.;Body mass index. Timepoint: Before intervention and three months after intervention. Method of measurement: Scale and measuring tape.;Waist circumference. Timepoint: Before intervention and three months after intervention. Method of measurement: By measuring tape.;Hip circumference. Timepoint: Before intervention and three months after intervention. Method of measurement: By measuring tape.;Insulin. Timepoint: Before intervention and three months after intervention. Method of measurement: Blood sampling.;Lipid profile. Timepoint: Before intervention and three months after intervention. Method of measurement: Blood sampling. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNasrin Dokht Zamani
Faculty of Traditional Medicine, Shiraz University of Medical Sciences
Outcome results
None listed