The effect of vitamin C on inflammatory markers and hemodynamic parameters in patients undergoing coronary artery bypass surgery

The Effect of vitamin C on inflammatory markers and hemodynamic parameters in patients undergoing Coronary Artery Bypass Surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015120922466N10

Enrollment

Registered

2016-06-13

Start date

2016-06-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Bypass Surgery. T82.9 Unspecified complication of cardiac and vascular prosthetic device, implant and graft

Interventions

Intervention 1: Intervention group: 2 grams of Vitamin C (4 ampoules 5 ml) intravenously 10 minutes after induction of anesthesia. Intervention 2: Control group:normal saline solution Equivalent 4 am

Treatment - Drugs

Placebo

Intervention group: 2 grams of Vitamin C (4 ampoules 5 ml) intravenously 10 minutes after induction of anesthesia

Control group:normal saline solution Equivalent 4 ampoules 5 ml intravenously 10 minutes after induction of anesthesia

Eligibility

Sex/Gender

All

Age

40 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria included patients undergoing elective coronary artery bypass graft surgery with cardiopulmonary bypass, aged between 40 and 80 years, at the same time non-malignant disease, no history of hypersensitivity reactions, patients with atrial fibrillation admitted lack of experience, lack of large trauma or major surgery less than 6 months of surgery, lack of ejection fraction less than 30%, not having kidney failure. Exclusion criteria: drug reaction and any problems with anesthesia during surgery, atrial fibrillation during operation.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Inflammatory markers (interleukin 6 and hsCRP). Timepoint: 10 minutes before the intervention and after the intervention (the end of CPB and 24 hours after surgery. Method of measurement: Using the method of testing and enzyme-linked immunosorbent.;Hemodynamic parameters. Timepoint: 10 minutes before the intervention and after the intervention (the end of CPB and 24 hours after surgery. Method of measurement: check- list.	—

Measure

Time frame

Inflammatory markers (interleukin 6 and hsCRP). Timepoint: 10 minutes before the intervention and after the intervention (the end of CPB and 24 hours after surgery. Method of measurement: Using the method of testing and enzyme-linked immunosorbent.;Hemodynamic parameters. Timepoint: 10 minutes before the intervention and after the intervention (the end of CPB and 24 hours after surgery. Method of measurement: check- list.

—

Secondary

Measure	Time frame
Gastrointestinal side effects. Timepoint: A week after intervention and at the end of intervention. Method of measurement: Visual.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShahnaz Pouladi

Bushehr University of Medical Sciences

Research(AT) Bpums.Ac.Ir; Sh.pooladi@bpums.ac.ir+98 77 3345 0187

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026