recurrent abortion. Spontaneous abortion
Conditions
Interventions
Intervention 1: intervention group: After confirming the positive pregnancy test, patients will receive tablet of 200 mg hydroxychloroquine twice a day up to the twentieth week of pregnancy.Sonography
Treatment - Drugs
intervention group: After confirming the positive pregnancy test, patients will receive tablet of 200 mg hydroxychloroquine twice a day up to the twentieth week of pregnancy.Sonography will be done in
control group: After confirming the positive pregnancy test, patients will receive placebo twice a day up to the twentieth week of pregnancy.Sonography will be done in weeks of 6-8, 11-13 and 18-22 of
Sponsors
Experimental Medicine Research Centerof Tehran University of Medical Science,Vice chancellor for res
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: inclusion criteria : women with more than 2 unexplained abortion exclusion criteria: women with rheumatoid; lupus erythematosus; underlying and heart diseases; smoking; consumption of alcohol and supplement; radiation contact
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Spontaneous abortion. Timepoint: any time during study. Method of measurement: observational. | — |
Secondary
| Measure | Time frame |
|---|---|
| Intrauterine death. Timepoint: after 20 weeks of gestation. Method of measurement: observational.;Preeclampsia. Timepoint: all the duration of pregnancy. Method of measurement: clinical and laboratory examination.;Low birth weight. Timepoint: after birth. Method of measurement: weighing.;Preterm labor. Timepoint: before 37 th week of gestation. Method of measurement: observational.;Congenital morphological abnormalities. Timepoint: after birth. Method of measurement: observational. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Reihaneh Pirjani
Arash Women 's Hospital, Tehran University of Medical sciences
Outcome results
None listed