The effect of admixture of clonidine and lidocaine as dental anesthesia solution on postoperative pain

Evaluation the effect of admixture of clonidine and lidocaine in comparison with epinephrine and lidocaine on postoperative pain after single visit root canal therapy of mandibular molars with irreversible pulpitis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201512076578N33

Enrollment

100

Registered

2015-12-18

Start date

2015-12-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irreversible pulpitis. Diseases of pulp and periapical tissues, Pulpitis

Interventions

Intervention 1: Control group : 1.8 mL of 2% lidocaine with epinephrine 1:80000 (L+Epi) at a concentration of 12.5 µg/mL (Persicaine, Darupakhsh, Tehran, Iran) applied by using conventional inferior a

Treatment - Drugs

Control group : 1.8 mL of 2% lidocaine with epinephrine 1:80000 (L+Epi) at a concentration of 12.5 µg/mL (Persicaine, Darupakhsh, Tehran, Iran) applied by using conventional inferior alveolar nerve bl

Intervention group: 1.8 mL of 2% lidocaine with clonidine (L+Clo) at a concentration of 15 µg/mL applied by using conventional inferior alveolar nerve block injection technique.

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: The inclusion criteria: 18 years of age up to 60; in good health(ASA I (classification of the American Society of Anesthesiologists)); having at least one mandibular molar teeth with irreversible pulpitis criteria The exclusion criteria: Patients taking beta-blockers or being medicated with any opioids preoperatively; drug abusers; pregnant or nursing mothers; those with a contraindication for the use of clonidine; those known to be allergic to clonidine; those with orofacial infection/inflammation

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: 6, 12, 24, 36, 48, 72. Method of measurement: Heft-Parker visual analogue scale (VAS).	—

Countries

Iran (Islamic Republic of)

Contacts

Public Contact?Dr. Elham Shadmehr

Isfahan university of medical sicence

elham.shadmer@gmail.com+98 31 3440 8524

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026