The effect of mechanical ventilation with two different pressure levels on the incidence of pneumonia

Comparison of pneumonia incidence in head trauma patients under pressure control mechanical ventilation by two different level of pressure

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201512065363N6

Enrollment

120

Registered

2016-01-22

Start date

2015-03-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Ventilator Associated Pneumonia. Condition 2: Ventilator Associated Pneumonia. Influenza due to certain identified influenza virus Pneumonia, organism unspecified

Interventions

Intervention 1: The first group is placed under mechanical ventilation with the following settings: Mode = Pressure control ventilation. Pressure level = 25. PEEP =0-5 CmH2O. FiO2 = 50%. PS = 5 -1 CmH

Prevention

The first group is placed under mechanical ventilation with the following settings: Mode = Pressure control ventilation. Pressure level = 25. PEEP =0-5 CmH2O. FiO2 = 50%. PS = 5 -1 CmH2O

The second group is placed under mechanical ventilation with the following settings Mode = Pressure control ventilation. Pressure level = 35. PEEP = 5 CmH2O. FiO2 = 50%. PS = 5 – 10 CmH2O

Eligibility

Sex/Gender

All

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: PaO2/FIO2 >350; Age between 20 to 50 years; The absence of pneumonia;The absence of heart failure; No history of lung disease; The absence of ALI and ARDS; Dissatisfaction of patients and patients' families; Not receiving antibiotics; The absence of infectious disease exclusion criteria: The patient died in less than 14 days after entry into the study; Pneumonia or sepsis in less than 72 hours after inclusion

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pneumonia. Timepoint: Third day, Sixth day, Ninth day. Method of measurement: Clinical Pulmonary Infection Score.	—

Secondary

Measure	Time frame
Connection to ventilator days. Timepoint: End of the study. Method of measurement: Records.;Length of ICU stay. Timepoint: End of the study. Method of measurement: Records.;Mortality during hospitalization in ICU. Timepoint: End of the study. Method of measurement: Records.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Hamide Karimi

Zanjan University of Medical Sciences

echkey@gmail.com+98 24 3313 0001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026