The Effect of Dexmedetomidine on renal colic

Randomized clinical trial of Dexmedetomidine efficacy on acute renal colic in comparison with Ketorolac presenting to the emergency department

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015120625402N1

Enrollment

160

Registered

2015-12-17

Start date

2015-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal colic. Unspecified renal colic

Interventions

Intervention 1: Intervention Group: Receiving intravenous Dexmedetomidine (200mcg/ml vials) with a dose of 1 gram in 100?ml normal saline during 10 minutes (a 1-h study period, Time Frame: 20 minutes

Treatment - Drugs

Intervention Group: Receiving intravenous Dexmedetomidine (200mcg/ml vials) with a dose of 1 gram in 100?ml normal saline during 10 minutes (a 1-h study period, Time Frame: 20 minutes interval) and me

Control Group: Receiving intravenous Ketorolac (30 mg /ml vials) with a dose of 1 gram in 100?ml normal saline during 10 minutes (a 1-h study period, Time Frame: 20 minutes interval) and measuring the

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: typical physical complaints; a pain intensity between 3 to 10 on a 10 cm visual analogue scale (VAS) marked by the patient; a ureteric or kidney stone verified by ultrasonography and/or native abdominal X-ray; informed consent by the patient; and in women of fertile age, the apparent use of efficient contraception Exclusion criteria: Age 55y/o; Pain score 38 °C; History or documents suggesting cardiac, liver, respiratory or renal diseases; History of GIB or active GI ulcer; History of seizure; History of metabolic Disorder; Pregnancy; Suspicious abdominal aortic aneurism or dissection; Inability to speech

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Duration and intensity of pain in renal colic. Timepoint: Baseline. Method of measurement: visual analogue pain scale (VPAS).	—

Secondary

Measure	Time frame
Decrease in duration and intensity of pain in renal colic. Timepoint: 20, 40, and 60 min after the first injection. Method of measurement: visual analogue pain scale (VPAS).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mozhdeh Mosaffa

Ahvaz Jundishapur University of Medical Sciences

mosaffa.m@ajums.ac.ir+98 61 3374 3079

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026