fever and neutropenia due to chemotherapy. Agranulocytosis secondary to cancer chemotherapy
Conditions
Interventions
Intervention 1: Intervention group: Cefpime 50mg / kg every eight hours. Intervention 2: Control group: aminoglycoside (gentamicin 2-2.5 mg / kg every eight hours / amikacin 15-22.5 mg / kg daily in t
Sponsors
Oroumia University of Medical Sciences
Eligibility
Sex/Gender
All
Age
3 Months to 18 Years
Inclusion criteria
Inclusion criteria: Age between 3 months to 18 years Diagnosis of fever and neutropenia (oral temperature = 38.3 at one measurement or =38 temperature that lasts for one hour, with ANC <500 ) Cancer Consent of the parent or legal guardian to participate in the study protocol No contraindications for receiving the studied antibiotics (gentamicin, amikacin, ceftriaxone, cefepime)
Exclusion criteria
Exclusion criteria: Patients with a history of type 1 allergy to one of the above antibiotics Patients who have a positive culture with specific microorganism on admission Patients in need who need extensive antibiotic coverage from the beginning of hospitalization
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean hosptial stay. Timepoint: After discharge. Method of measurement: Counting days.;Mean ICU stay. Timepoint: After discharge. Method of measurement: Counting days.;Frequency of the need to escalate the antibiotic regimen. Timepoint: After discharge. Method of measurement: Checking the patient's file.;The mean duration required to stop the fever. Timepoint: After discharge. Method of measurement: Counting days. | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean ICU stay. Timepoint: After discharge. Method of measurement: Counting days.;Frequency of the need to escalate the antibiotic regimen. Timepoint: After discharge. Method of measurement: Checking the patient's file.;The mean duration required to stop the fever. Timepoint: After discharge. Method of measurement: Counting days. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZahra Alimohammad Ghelichkhan
Oroumia University of Medical Sciences
Outcome results
None listed