Intradialytic hypotension. Hypotension of hemodialysis
Conditions
Interventions
Intervention 1: Intervention group: first intervention group for 2 weeks receives 5 mg midodrine half an hour before hemodialysis. Then, after a washout period of one week, for 4 weeks receives venlaf
Sponsors
Oroumia University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Informed consent to participate in the study Being on maintenance hemodialysis for at least 3 months Intradialytic hypotension in at least 50% of dialysis sessions in the last month (Intradialytic hypotension definition according to KDOQI: A decrease in systolic blood pressure of 20mmHg or more or 10mmHg in mean arterial pressure that can cause symptoms of intradialytic hypotension including abdominal discomfort, yawning, sighing, nausea vomiting, muscle cramps, agitation, dizziness, fainting, and restlessness.)
Exclusion criteria
Exclusion criteria: History of venlafaxine or midodrine intolerance in previous consumption Severe hepatic failure (Child-Pugh C) Present use of MAOIs or use during the last 2 weeks Present use of linezolid or serotonergic medications History of depression/mania or active psychiatric disease Seizure history or being under treatment for it Any other concomitant disease other than intradialytic hypotension that the patient's hypotension can be attributed to it (such as tamponade, active cancer, PTE, dehydration, bleeding, shock) History of ACS or CAD Not consenting to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nadir Mean Arterial Pressure. Timepoint: Dialysis even sessions. Method of measurement: Sphygmomonometer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Nadir systolic blood pressure. Timepoint: Dialysis even sessions. Method of measurement: Sphygmomonometer.;Nadir diastolic blood pressure. Timepoint: Dialysis even sessions. Method of measurement: Sphygmomonometer.;Number of intradialytic hypotension episodes in each group. Timepoint: Dialysis even sessions. Method of measurement: Observation by educated and qualified nurse.;Pre and post dialysis systolic blood pressure difference. Timepoint: Dialysis even sessions. Method of measurement: Sphygmomonometer.;Pre and post dialysis diastolic blood pressure difference. Timepoint: Dialysis even sessions. Method of measurement: Sphygmomonometer.;Pre and post dialysis mean arterial pressure difference. Timepoint: Dialysis even sessions. Method of measurement: Sphygmomonometer.;Frequency of adverse drug reactions in each intervention group. Timepoint: From the start to the end of each medication intervention in each group. Method of measurement: Patient interview. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZahra Alimohammad Ghelich Khan
Oroumia University of Medical Sciences
Outcome results
None listed