Patent ductus arteriosus. Patent ductus arteriosus
Conditions
Interventions
Intervention 1: The first group of patients treated with ibuprofen at a dose of 10 mg/kg/stat and then 5 mg/kg/12h to two doses. Intervention 2: The second group of patients treated with acetaminophen
Treatment - Drugs
The first group of patients treated with ibuprofen at a dose of 10 mg/kg/stat and then 5 mg/kg/12h to two doses.
The second group of patients treated with acetaminophen for two days at a dose of 15 mg/kg/6h (8 doses).
Sponsors
Qazvin University of Medical Sciences
Eligibility
Sex/Gender
All
Age
1 Days to 14 Days
Inclusion criteria
Inclusion criteria: Inclusion Criteria: Gestational age less than or equal to 34 weeks; Birth elapsed time less than or equal to 14 days; PDA diagnosis based on echocardiography findings. Exclusion Criteria: Any type of congenital heart disease is to keep the blood flow needed PDA; Life-threatening infections; Grade 3-4 intraventricular hemorrhage (within recent 24 hours); Urinary output less than 1mg/kg/h in last 8 hours; Serum creatinine level higher than 88 µmol/L; platelet counts less than 109×50 per liter; Hyperbilirobinemia requiring blood transfusions; Active necrotizing enterocolitis or bowel perforation; Liver dysfunction; Gastrointestinal bleeding; Retinopathy; Bronchopulmonary dysplasia; Lack of parental consent.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart murmur. Timepoint: Before intervention - three days after the intervention. Method of measurement: Auscultation - Echocardiography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Bleeding Including the gastrointestinal tract, urinary tract and respiratory tract. Timepoint: During the intervention. Method of measurement: Clinical observation and tests such as analysis of urine and faeces. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactTahereh Jangjoo Pirbazari
Qazvin University of Medical Sciences
Outcome results
None listed