Perennial allergic rhinitis. Other allergic rhinitis
Conditions
Interventions
Intervention 1: In intervention group synbiotic capsule give once a day for two month. Intervention 2: In control group placebo capsule give once a day for two month with immunotherapy. Intervention 3
Treatment - Drugs
In intervention group synbiotic capsule give once a day for two month
Sponsors
Vice chancellor for research, Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria:patients with persistent allergic rhinitis; Mashhad residents and surrounding towns; Have a positive skin test with Aeroallergen; Cooperate in projects Exclusion criteria: A history of autoimmune disease; Systemic corticosteroids or immunosuppressive drugs consumption and effective on immune system; Pregnant Women; Patients with immunodeficiency; Patients with malnutrition; Use Antibiotic during synbiotic consumption
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of life. Timepoint: Before the intervention and two month later. Method of measurement: Snot 22 questionnaire.;IL4. Timepoint: Before the intervention and two month later. Method of measurement: Flow cytometry.;T-reg. Timepoint: Before the intervention and two month later. Method of measurement: Flow cytometry.;IFN- gamma. Timepoint: Before the intervention and two month later. Method of measurement: Flow cytometry. | — |
Secondary
| Measure | Time frame |
|---|---|
| Systemic reactions to immunotherapy. Timepoint: At every turn immunotherapy. Method of measurement: Clinical. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNasrin Moazzen, MD
Mashhad University of Medical Sciences
Outcome results
None listed