Effects of Cichorium Intybus L. Leaf Extract on improvement of the clinical status of patients with periodontal

The effects of non-surgical periodontal therapy with Cichorium Intybus L. Leaf Extract on antioxidant status, inflammation and blood lipid status of patients with periodontal disease

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015112825274N1

Enrollment

Registered

2016-01-14

Start date

2014-04-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

periodental. Periodontal disease, unspecified

Interventions

Intervention 1: Intervention group1: Consumption of two one-gram capsules daily containing total of 2 grams of Cichorium Intybus L. Leaf extract (By using fresh leaf of Cichorium Intybus L from Kan

Intervention group1: Consumption of two one-gram capsules daily containing total of 2 grams of Cichorium Intybus L. Leaf extract (By using fresh leaf of Cichorium Intybus L from Kandovan city, loca

Control group: Consumption of two one-gram capsules daily containing 2 grams of wheat flour (capsules prepared by the Center for Pharmaceutical Research, Tabriz University of Medical Sciences), in the

Eligibility

Sex/Gender

All

Age

30 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: age over 30 years; having periodontal disease (PPD more than 4 millimeter) in at least one site in the three quarters of the mouth); BMI more than 18.5 Kilogram/ square meter. Exclusion criteria: lack of cooperation; pregnancy and lactation; smoking; use of dietary supplements and antioxidant; Consumption of anti cariogenic gum; Consumption of drugs that suppress the immune system; changes in diet pattern and hyperlipidemia.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Interleukin-6. Timepoint: Before and two months after intervention. Method of measurement: ELISA.;Hs-CRP. Timepoint: Before and two months after intervention. Method of measurement: ELISA.;Malon de aldehid (MDA). Timepoint: Before and two months after intervention. Method of measurement: chemical method (Kit).;Blood uric acid. Timepoint: Before and two months after intervention. Method of measurement: chemical method.;Triglycerides. Timepoint: Before and two months after intervention. Method of measurement: Enzymatic.;Cholesterol. Timepoint: Before and two months after intervention. Method of measurement: Enzymatic.;HDL-cholesterol. Timepoint: Before and two months after intervention. Method of measurement: Enzymatic.;Total antioxidant capacity of blood. Timepoint: Before and two months after intervention. Method of measurement: Enzymatic.	—

Measure

Time frame

Interleukin-6. Timepoint: Before and two months after intervention. Method of measurement: ELISA.;Hs-CRP. Timepoint: Before and two months after intervention. Method of measurement: ELISA.;Malon de aldehid (MDA). Timepoint: Before and two months after intervention. Method of measurement: chemical method (Kit).;Blood uric acid. Timepoint: Before and two months after intervention. Method of measurement: chemical method.;Triglycerides. Timepoint: Before and two months after intervention. Method of measurement: Enzymatic.;Cholesterol. Timepoint: Before and two months after intervention. Method of measurement: Enzymatic.;HDL-cholesterol. Timepoint: Before and two months after intervention. Method of measurement: Enzymatic.;Total antioxidant capacity of blood. Timepoint: Before and two months after intervention. Method of measurement: Enzymatic.

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Secondary

Measure	Time frame
Weight. Timepoint: Before and two months after intervention. Method of measurement: scale.;Height. Timepoint: Before and two months after intervention. Method of measurement: Stadiometer.;Energy intake. Timepoint: Before and two months after intervention. Method of measurement: recall.;Carbohydrate intake. Timepoint: Before and two months after intervention. Method of measurement: recall.;Protein intake. Timepoint: Before and two months after intervention. Method of measurement: recall.;Fat intake. Timepoint: Before and two months after intervention. Method of measurement: recall.;Saturated Fat. Timepoint: Before and two months after intervention. Method of measurement: recall.;Vitamin A. Timepoint: Before and two months after intervention. Method of measurement: recall.;Vitamin C. Timepoint: Before and two months after intervention. Method of measurement: recall.;Vitamin E. Timepoint: Before and two months after intervention. Method of measurement: recall.;Betacaroten. Timepoint: Before and two months after intervention. Method of measurement: recall.	—

Measure

Time frame

Weight. Timepoint: Before and two months after intervention. Method of measurement: scale.;Height. Timepoint: Before and two months after intervention. Method of measurement: Stadiometer.;Energy intake. Timepoint: Before and two months after intervention. Method of measurement: recall.;Carbohydrate intake. Timepoint: Before and two months after intervention. Method of measurement: recall.;Protein intake. Timepoint: Before and two months after intervention. Method of measurement: recall.;Fat intake. Timepoint: Before and two months after intervention. Method of measurement: recall.;Saturated Fat. Timepoint: Before and two months after intervention. Method of measurement: recall.;Vitamin A. Timepoint: Before and two months after intervention. Method of measurement: recall.;Vitamin C. Timepoint: Before and two months after intervention. Method of measurement: recall.;Vitamin E. Timepoint: Before and two months after intervention. Method of measurement: recall.;Betacaroten. Timepoint: Before and two months after intervention. Method of measurement: recall.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAhmad Zare Javid

Ahvaz Jundishapur University of Medical Sciences

zarejavid-a@ajums.ac.ir+98 61 3373 8319

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026