The effects of rutin supplement on the brain of type 2 diabetes mellitus patients

The effects of rutin flavonoid supplement on brain white matter neural tracts volume in type 2 diabetes mellitus patients by MRI

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20151128025274N6

Enrollment

Registered

2021-01-10

Start date

2021-01-20

Completion date

Unknown

Last updated

2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes mellitus. Type 2 diabetes mellitus

Interventions

Intervention 1: Intervention group: Every day, one tablet of 1 g rutin (containing 500 mg of pure rutin and 500 mg other compounds include di-calcium phosphate, microcrystalline cellulose, plant cellu

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Willingness to participate in the study People between 20 to 60 years old in both sexes, Over at least 2 years from time of diagnosis of type 2 diabetes mellitus Body mass index (BMI) less than 35 (BMI = 35) Glycosylated hemoglobin (HbA1c) between 6.5 to 11%

Exclusion criteria

Exclusion criteria: Developing complications from diabetes such as renal failure Diabetic patients taking insulin Thyroid disease Anemia Pregnancy, lactation Smokers Use of other dietary supplements, probiotics and anti-inflammatory drugs Use of any antioxidant supplements in the last 3 months Use of immunosuppressive drugs Following of special diets other than the diet specific to diabetic patients, History of brain surgery and brain tumors.

Design outcomes

Primary

Measure	Time frame
Fractional anisotropy (FA). Timepoint: Before and after the intervention. Method of measurement: Using Diffusion Tensor Imaging (DTI) and analysis with functional magnetic resonance imaging of the brain software library (FSL) software.;MD: Mean diffusivity. Timepoint: Before and after the intervention. Method of measurement: Using Diffusion Tensor Imaging (DTI) and analysis with functional magnetic resonance imaging of the brain software library (FSL) software.;RD: Radial diffusivity. Timepoint: Before and after the intervention. Method of measurement: Using Diffusion Tensor Imaging (DTI) and analysis with functional magnetic resonance imaging of the brain software library (FSL) software.;AD: Axial diffusivity. Timepoint: Before and after the intervention. Method of measurement: Using Diffusion Tensor Imaging (DTI) and analysis with functional magnetic resonance imaging of the brain software library (FSL) software.;The volume of white matter of the throwing, radial and communication fibers of the brain. Timepoint: Before and after the intervention. Method of measurement: Using Diffusion Tensor Imaging (DTI) and analysis with functional magnetic resonance imaging of the brain software library (FSL) software.;The volume of gray matter of the brain. Timepoint: Before and after the intervention. Method of measurement: Using Diffusion Tensor Imaging (DTI) and analysis with functional magnetic resonance imaging of the brain software library (FSL) software.	—

Measure

Time frame

Fractional anisotropy (FA). Timepoint: Before and after the intervention. Method of measurement: Using Diffusion Tensor Imaging (DTI) and analysis with functional magnetic resonance imaging of the brain software library (FSL) software.;MD: Mean diffusivity. Timepoint: Before and after the intervention. Method of measurement: Using Diffusion Tensor Imaging (DTI) and analysis with functional magnetic resonance imaging of the brain software library (FSL) software.;RD: Radial diffusivity. Timepoint: Before and after the intervention. Method of measurement: Using Diffusion Tensor Imaging (DTI) and analysis with functional magnetic resonance imaging of the brain software library (FSL) software.;AD: Axial diffusivity. Timepoint: Before and after the intervention. Method of measurement: Using Diffusion Tensor Imaging (DTI) and analysis with functional magnetic resonance imaging of the brain software library (FSL) software.;The volume of white matter of the throwing, radial and communication fibers of the brain. Timepoint: Before and after the intervention. Method of measurement: Using Diffusion Tensor Imaging (DTI) and analysis with functional magnetic resonance imaging of the brain software library (FSL) software.;The volume of gray matter of the brain. Timepoint: Before and after the intervention. Method of measurement: Using Diffusion Tensor Imaging (DTI) and analysis with functional magnetic resonance imaging of the brain software library (FSL) software.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHadi Bazyar

Ahvaz University of Medical Sciences

hadibazyar2015@gmail.com+98 61 3333 0747

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026