Male Infertility. Male infertility
Conditions
Interventions
Intervention 1: Intervention group: Patients in the intervention group will receive vitamin D supplementation (in tablet form) at a dose of 4,000 units per day for 12 weeks. Vitamin D supplementation
Sponsors
Ahvaz University of Medical Sciences
Eligibility
Sex/Gender
Male
Age
20 Years to 49 Years
Inclusion criteria
Inclusion criteria: Willing to participate in the study and filling out the informed consent form They should be infertile (no conception after 12 months intercourse without any contraception) Age 20-49 y.o. Idiopathic oligoasthenozoospermia according to WHO criteria Vitamin D levels = 30 ng, ml Normal hormonal profile
Exclusion criteria
Exclusion criteria: Any known causes of infertility (such as infection in genitourinary (GU) tract, anatomical abnormality in GU tract, immunological and etc.) Any chronic disease and any surgery in GU tract Any antioxidant supplements consumption, drug treatment or alcohol consumption during last 3 months Candidate for ICSI (sperm injection inside the cytoplasm) Contact with pesticides, heavy metals and solvents Severe physical activity and body mass index (BMI) higher than 30 and less than 18.5 kg,m2
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total sperm count. Timepoint: Before intervention and 12 weeks after the intervention. Method of measurement: Spermatogram.;Sperm Motility. Timepoint: Before intervention and 12 weeks after the intervention. Method of measurement: Spermatogram.;Serum and seminal Total Antioxidant Capacity. Timepoint: Before intervention and 12 weeks after the intervention. Method of measurement: ELISA.;Serum and seminal Malondialdehyde. Timepoint: Before intervention and 12 weeks after the intervention. Method of measurement: ELISA.;Seminal 8-hydroxy Deoxy guanosine. Timepoint: Before intervention and 12 weeks after the intervention. Method of measurement: ELISA.;Serum 25 hydroxyvitamin D. Timepoint: Before intervention and 12 weeks after the intervention. Method of measurement: ELISA.;Serum and seminal calcium. Timepoint: Before the start of the intervention and 12 weeks after the intervention. Method of measurement: Calorimetry.;Serum phosphate. Timepoint: Before intervention and 12 weeks after the intervention. Method of measurement: Calorimetry.;Spermatozoa intracellular calcium. Timepoint: Before intervention and 12 weeks after the intervention. Method of measurement: ELISA.;Serum Parathormon. Timepoint: Before intervention and 12 weeks after the intervention. Method of measurement: ELISA. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactLeila Maghsoumi-Norouzabad
Ahvaz University of Medical Sciences
Outcome results
None listed